Effect of Uncaria gambir and Uncaria sclerophylla on pulmonary-thromboembolism mice

Aditya Sindu Sakti, Astari Rachma Nityasa, Fadlina Chany Saputri

Research output: Contribution to journalArticle

Abstract

Background: Previous studies on virtual screening on P2Y12 receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. Objective: In this study, we investigated the effect of Uncaria gambir and Uncaria sclerophylla extract on survival rate and bleeding time as antithrombotic in vivo. Methods: Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). U. gambir and U. sclerophylla were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. Results: U. gambir and U. sclerophylla able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group. Conclussion: Both of U. gambir and U. sclerophylla prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalPharmacognosy Journal
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Antithrombotic
  • Bleeding time
  • Pulmonary thromboembolism
  • Survival rate
  • Uncaria gambir
  • Uncaria sclerophylla

Fingerprint Dive into the research topics of 'Effect of Uncaria gambir and Uncaria sclerophylla on pulmonary-thromboembolism mice'. Together they form a unique fingerprint.

  • Cite this