TY - JOUR
T1 - Effect of PEG Incorporation on Physicochemical and in vitro Degradation of PLLA/PDLLA Blends
T2 - Application in Biodegradable Implants
AU - Chalid, Mochamad
AU - Gustiraharjo, Gifrandy
AU - Pangesty, Azizah Intan
AU - Adyandra, Alyssa
AU - Whulanza, Yudan
AU - Supriadi, Sugeng
N1 - Funding Information:
Funding Statement: This work was supported by Universitas Indonesia under Grant PUTI 2020 (No. NKB-4325/UN2.RST/HKP.05.00/2020).
Publisher Copyright:
© 2023, Tech Science Press. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Polyethylene glycol (PEG) was added at different concentrations to the blend of poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid)(PDLLA) to tailor the properties. The differential scanning calorimetry (DSC) measurement showed that all blends were miscible due to shifting a single glass transition temperature into a lower temperature for increasing PEG content. The DSC, FTIR, and XRD results implied the crystallinity enhancement for PEG content until 8 wt%, then decreased at 12 wt% PEG. The XRD result indicated the homo crystalline phase formation in all blends and no stereocomplex crystal. The in vitro degradation study indicated that PEG content is proportional to the degradation rate. The highest weight loss after 28 days was achieved at 12 wt% PEG. The FTIR analysis showed a structural evolution overview during hydrolytic degradation, viz. increasing and decreasing crystallinity during 14 days for the blend without and with PEG, respectively. In conclusion, the PEG addition increased crystallinity and degradation rate of the PLLA/PDLLA mixture, but PEG higher amounts led to a decrease in crystallinity, and the weight loss was intensified. This can be useful for tuning PLA-based biomaterials with the desired physicochemical properties and appropriate degradation rates for applications in drug delivery/ tissue engineering.
AB - Polyethylene glycol (PEG) was added at different concentrations to the blend of poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid)(PDLLA) to tailor the properties. The differential scanning calorimetry (DSC) measurement showed that all blends were miscible due to shifting a single glass transition temperature into a lower temperature for increasing PEG content. The DSC, FTIR, and XRD results implied the crystallinity enhancement for PEG content until 8 wt%, then decreased at 12 wt% PEG. The XRD result indicated the homo crystalline phase formation in all blends and no stereocomplex crystal. The in vitro degradation study indicated that PEG content is proportional to the degradation rate. The highest weight loss after 28 days was achieved at 12 wt% PEG. The FTIR analysis showed a structural evolution overview during hydrolytic degradation, viz. increasing and decreasing crystallinity during 14 days for the blend without and with PEG, respectively. In conclusion, the PEG addition increased crystallinity and degradation rate of the PLLA/PDLLA mixture, but PEG higher amounts led to a decrease in crystallinity, and the weight loss was intensified. This can be useful for tuning PLA-based biomaterials with the desired physicochemical properties and appropriate degradation rates for applications in drug delivery/ tissue engineering.
KW - crystallinity
KW - degradation
KW - PDLLA
KW - PEG
KW - PLLA
UR - http://www.scopus.com/inward/record.url?scp=85162657248&partnerID=8YFLogxK
U2 - 10.32604/jrm.2023.026788
DO - 10.32604/jrm.2023.026788
M3 - Article
AN - SCOPUS:85162657248
SN - 2164-6325
VL - 11
SP - 3043
EP - 3056
JO - Journal of Renewable Materials
JF - Journal of Renewable Materials
IS - 7
ER -