Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population

Robi Sinambela; Bambang Tri Hartomo; Yurnadi Hanafi Midoen; Nurtami Soedarsono; Ferry Pergamus Gultom; Elza Ibrahim Auerkari

doi:10.1063/1.5139363

Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population

Robi Sinambela, Bambang Tri Hartomo, Yurnadi Hanafi Midoen, Nurtami Soedarsono, Ferry Pergamus Gultom, Elza Ibrahim Auerkari

Department of Oral Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The high prevalence of head and neck cancer in Indonesia could imply possible population-specific causative factors. The polymorphisms of the p21 gene may modify important cellular defenses to carcinogenesis through the involvement of p21 in the cell cycle. It is known that p21 has a role as a mediator of p53 tumor suppressor that is involved in DNA repair and apoptosis. This study aimed to investigate the possible association of p21 (C98A) polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) in Indonesia. The PCR-RFLP method was used to genotype stored DNA samples from 50 HNSCC patients and 50 healthy control subjects. The CA genotype was the most common variant in both case and control groups. Conclusion: There was no significant association between the genetic polymorphisms of p21 (C98A) with HNSCC in the tested Indonesian population.

Original language	English
Title of host publication	4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publication	Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019
Editors	Kenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419445
DOIs	https://doi.org/10.1063/1.5139363
Publication status	Published - 10 Dec 2019
Event	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia Duration: 22 Jul 2019 → 24 Jul 2019

Publication series

Name	AIP Conference Proceedings
Volume	2193
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/Territory	Indonesia
City	Padang, West Sumatera
Period	22/07/19 → 24/07/19

Keywords

cancer
Indonesia
p21
p53 polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.5139363

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Sinambela, R., Hartomo, B. T., Midoen, Y. H., Soedarsono, N., Gultom, F. P., & Auerkari, E. I. (2019). Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population. In K. Lischer, T. Abuzairi, S. F. Rahman, & M. Gozan (Eds.), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019 [040001] (AIP Conference Proceedings; Vol. 2193). American Institute of Physics Inc.. https://doi.org/10.1063/1.5139363

Sinambela, Robi ; Hartomo, Bambang Tri ; Midoen, Yurnadi Hanafi et al. / Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population. 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. editor / Kenny Lischer ; Tomy Abuzairi ; Siti Fauziyah Rahman ; Misri Gozan. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

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abstract = "The high prevalence of head and neck cancer in Indonesia could imply possible population-specific causative factors. The polymorphisms of the p21 gene may modify important cellular defenses to carcinogenesis through the involvement of p21 in the cell cycle. It is known that p21 has a role as a mediator of p53 tumor suppressor that is involved in DNA repair and apoptosis. This study aimed to investigate the possible association of p21 (C98A) polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) in Indonesia. The PCR-RFLP method was used to genotype stored DNA samples from 50 HNSCC patients and 50 healthy control subjects. The CA genotype was the most common variant in both case and control groups. Conclusion: There was no significant association between the genetic polymorphisms of p21 (C98A) with HNSCC in the tested Indonesian population.",

keywords = "cancer, Indonesia, p21, p53 polymorphism",

author = "Robi Sinambela and Hartomo, {Bambang Tri} and Midoen, {Yurnadi Hanafi} and Nurtami Soedarsono and Gultom, {Ferry Pergamus} and Auerkari, {Elza Ibrahim}",

note = "Funding Information: The authors wish to gratefully acknowledge the financial support from the Indonesian through the Universitas Indonesia (EIA). Publisher Copyright: {\textcopyright} 2019 Author(s).; 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 ; Conference date: 22-07-2019 Through 24-07-2019",

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Sinambela, R, Hartomo, BT, Midoen, YH, Soedarsono, N , Gultom, FP & Auerkari, EI 2019, Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population. in K Lischer, T Abuzairi, SF Rahman & M Gozan (eds), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019., 040001, AIP Conference Proceedings, vol. 2193, American Institute of Physics Inc., 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019, Padang, West Sumatera, Indonesia, 22/07/19. https://doi.org/10.1063/1.5139363

Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population. / Sinambela, Robi; Hartomo, Bambang Tri; Midoen, Yurnadi Hanafi et al.

4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. ed. / Kenny Lischer; Tomy Abuzairi; Siti Fauziyah Rahman; Misri Gozan. American Institute of Physics Inc., 2019. 040001 (AIP Conference Proceedings; Vol. 2193).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population

AU - Sinambela, Robi

AU - Hartomo, Bambang Tri

AU - Midoen, Yurnadi Hanafi

AU - Soedarsono, Nurtami

AU - Gultom, Ferry Pergamus

AU - Auerkari, Elza Ibrahim

PY - 2019/12/10

Y1 - 2019/12/10

N2 - The high prevalence of head and neck cancer in Indonesia could imply possible population-specific causative factors. The polymorphisms of the p21 gene may modify important cellular defenses to carcinogenesis through the involvement of p21 in the cell cycle. It is known that p21 has a role as a mediator of p53 tumor suppressor that is involved in DNA repair and apoptosis. This study aimed to investigate the possible association of p21 (C98A) polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) in Indonesia. The PCR-RFLP method was used to genotype stored DNA samples from 50 HNSCC patients and 50 healthy control subjects. The CA genotype was the most common variant in both case and control groups. Conclusion: There was no significant association between the genetic polymorphisms of p21 (C98A) with HNSCC in the tested Indonesian population.

AB - The high prevalence of head and neck cancer in Indonesia could imply possible population-specific causative factors. The polymorphisms of the p21 gene may modify important cellular defenses to carcinogenesis through the involvement of p21 in the cell cycle. It is known that p21 has a role as a mediator of p53 tumor suppressor that is involved in DNA repair and apoptosis. This study aimed to investigate the possible association of p21 (C98A) polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) in Indonesia. The PCR-RFLP method was used to genotype stored DNA samples from 50 HNSCC patients and 50 healthy control subjects. The CA genotype was the most common variant in both case and control groups. Conclusion: There was no significant association between the genetic polymorphisms of p21 (C98A) with HNSCC in the tested Indonesian population.

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KW - p21

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Sinambela R, Hartomo BT, Midoen YH, Soedarsono N , Gultom FP , Auerkari EI. Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population. In Lischer K, Abuzairi T, Rahman SF, Gozan M, editors, 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. American Institute of Physics Inc. 2019. 040001. (AIP Conference Proceedings). doi: 10.1063/1.5139363

Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population

Abstract

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Keywords

UN SDGs

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