Effect of P21(C98A) polymorphism on the risk of head and neck squamous cell carcinoma in an Indonesian population

Robi Sinambela, Bambang Tri Hartomo, Yurnadi Hanafi Midoen, Nurtami Soedarsono, Ferry Pergamus Gultom, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The high prevalence of head and neck cancer in Indonesia could imply possible population-specific causative factors. The polymorphisms of the p21 gene may modify important cellular defenses to carcinogenesis through the involvement of p21 in the cell cycle. It is known that p21 has a role as a mediator of p53 tumor suppressor that is involved in DNA repair and apoptosis. This study aimed to investigate the possible association of p21 (C98A) polymorphism with the risk of head and neck squamous cell carcinoma (HNSCC) in Indonesia. The PCR-RFLP method was used to genotype stored DNA samples from 50 HNSCC patients and 50 healthy control subjects. The CA genotype was the most common variant in both case and control groups. Conclusion: There was no significant association between the genetic polymorphisms of p21 (C98A) with HNSCC in the tested Indonesian population.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/TerritoryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • cancer
  • Indonesia
  • p21
  • p53 polymorphism

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