Effect of nanocurcumin on cisplatin-induced acute kidney injury: A focus on NRF2 and keap

Bashar Adi Wahyu Pandhita, Vivian Soetikno, Melva Louisa

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to investigate the effect of nanocurcumin (NC) against cisplatin-induced acute kidney injury, focusing on Nrf2 and Keap1. Methods: Male Sprague-Dawley rats (n=23) were divided into five groups (Control, CP, CP+Cur, CP+50 NC, and CP+100 NC) and sacrificed 7 days after treatment. Whole kidneys were collected for reverse transcription polymerase chain reaction (RT-PCR) analysis of Nrf2 and Keap1. Results: There were no statistically significant differences in the RT-PCR results among the groups (p>0.05). However, Keap1 expression was upregulated in rats treated with 100 mg of NC, which may have been caused by increased Nrf2 activation and activation of a negative feedback loop, which upregulated transcription of Keap1. Conclusion: NC increased Keap1 levels, but not significantly.

Original languageEnglish
Pages (from-to)152-154
Number of pages3
JournalInternational Journal of Applied Pharmaceutics
Volume10
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Cisplatin
  • Keap1
  • Nanocurcumin
  • Nephrotoxicity
  • Nrf2

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