TY - JOUR
T1 - Effect of Nanocurcumin in Combination with Methotrexate on Telomerase Activity, NF-kb Expression, and Proliferation Index of Bewo Choriocarcinoma Cells
AU - Subandi,
AU - Purbadi, Sigit
N1 - Publisher Copyright:
© 2023 Indonesian Society of Obstetrics and Gynecology. All Rights Reserved.
PY - 2023/4
Y1 - 2023/4
N2 - Objectives: To determine the anti-cancer effect of nanocurcumin on choriocarcinoma. Methods: This study observes the telomerase activity, NF-κB expression, and BrdU proliferation index in cultures of BeWo choriocarcinoma cell line (ATCC CCL-98) exposed to MTX and nanocurcumin in various doses. The sample used in this study consisted of 4 groups of BeWo cells that received a combination of MTX and nanocurcumin, and 2 other groups for positive and negative control. Results: There was a decrease in telomerase activity, NF-κB expression, and BrdU proliferation index in the 4 treatment groups compared to the negative and positive control group (p≤0.05). Conclusion: Nanocurcumin and MTX decrease telomerase expression, NF-κB expression, and the BrdU proliferation index in choriocarcinoma BeWo cell line culture faster than MTX alone.
AB - Objectives: To determine the anti-cancer effect of nanocurcumin on choriocarcinoma. Methods: This study observes the telomerase activity, NF-κB expression, and BrdU proliferation index in cultures of BeWo choriocarcinoma cell line (ATCC CCL-98) exposed to MTX and nanocurcumin in various doses. The sample used in this study consisted of 4 groups of BeWo cells that received a combination of MTX and nanocurcumin, and 2 other groups for positive and negative control. Results: There was a decrease in telomerase activity, NF-κB expression, and BrdU proliferation index in the 4 treatment groups compared to the negative and positive control group (p≤0.05). Conclusion: Nanocurcumin and MTX decrease telomerase expression, NF-κB expression, and the BrdU proliferation index in choriocarcinoma BeWo cell line culture faster than MTX alone.
KW - BrdU index proliferation
KW - choriocarcinoma
KW - methotrexate
KW - nanocurcumin
KW - NF-κB expression
KW - telomerase expression
UR - http://www.scopus.com/inward/record.url?scp=85162194508&partnerID=8YFLogxK
U2 - 10.32771/inajog.v11i2.1733
DO - 10.32771/inajog.v11i2.1733
M3 - Article
AN - SCOPUS:85162194508
SN - 2338-6401
VL - 11
SP - 105
EP - 111
JO - Indonesian Journal of Obstetrics and Gynecology
JF - Indonesian Journal of Obstetrics and Gynecology
IS - 2
ER -