Effect of monosodium glutamate (MSG) on spatial memory in rats (rattus norvegicus)

R. Razali, S. Redjeki, Ahmad Aulia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Monosodium Glutamate (MSG) is a commonly used flavor enhancer in food. Several studies have shown that high doses of MSG act as a neurotoxic or excitotoxic agent for cells in the central nervous system. This study aimed to determine the effect of MSG on spatial memory function. A total of 25 albino male rats of Sprague-Dawley strain (aged 8-10 weeks, weighing 150-200 g) were divided into five experimental groups (two control groups and three treatment groups that received 2 mg/g, 4 mg/g, or 6 mg/g oral MSG, respectively, for 30 days). Spatial memory test was performed using water-E maze before MSG administration and every week (5 times). After the last administration of MSG, all rats were killed. The data were analyzed by one-way ANOVA followed by the Least Significant Difference (LSD) post hoc test. The water-E maze test showed an increase in the number of errors made by the treatment group that received 4 mg/g and 6 mg/g of MSG, as well as an increase in time span to complete a memory test when compared with the control group after consumption of MSG for 30 days. In conclusion, this study showed that high MSG doses lead to a reduction in spatial memory function in rats.

Original languageEnglish
Title of host publicationAdvances in Biomolecular Medicine - Proceedings of the 4th BIBMC (Bandung International Biomolecular Medicine Conference) 2016 and the 2nd ACMM (ASEAN Congress on Medical Biotechnology and Molecular Biosciences) 2016
EditorsRobert Hofstra, Suthat Fucharoen, Noriyuki Koibuchi
PublisherCRC Press/Balkema
Pages71-74
Number of pages4
ISBN (Print)9781138631779
DOIs
Publication statusPublished - 2017
Event4th Bandung International Biomolecular Medicine Conference, BIBMC 2016 in conjuction with Asean Congress on Medical Biotechnology and Molecular Biosciences, ACMM 2016 - Bandung, Indonesia
Duration: 4 Oct 20166 Oct 2016

Publication series

NameAdvances in Biomolecular Medicine - Proceedings of the 4th BIBMC (Bandung International Biomolecular Medicine Conference) 2016 and the 2nd ACMM (ASEAN Congress on Medical Biotechnology and Molecular Biosciences) 2016

Conference

Conference4th Bandung International Biomolecular Medicine Conference, BIBMC 2016 in conjuction with Asean Congress on Medical Biotechnology and Molecular Biosciences, ACMM 2016
Country/TerritoryIndonesia
CityBandung
Period4/10/166/10/16

Keywords

  • Flavor enhancer
  • Monosodium Glutamate (MSG)
  • Rat
  • Spatial memory
  • Water e-maze

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