Effect of medium on charge transport properties of modified poly(dA)-poly(dT) DNA molecular wire

D. K. Suhendro, Efta Yudiarsah, Rosari Saleh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

By using tight binding Hamiltonian approach, the medium's effect on charge transport properties of modified poly(dA)-poly(dT) DNA molecular wire is studied. The DNA sequences used are modified poly(dA)-poly(dT) sequence by replacing 50 base pairs randomly with GC or CG base pairs. The DNA is contacted by metallic leads at both ends. The medium's effect on DNA is modeled as backbone onsite energy disorder. The DNA is taken to be at room temperature. The charge transport properties of the two sequences are studied by calculating the transmission probabilities of the charges using the scattering and transfer matrix methods simultaneously. Then the current-voltage (I-V) characteristics are calculated from the transmission probabilities using the Landauer-Büttiker Formalism. The theoretical differential conductance curve is then calculated from the I-V characteristic curve. The I-V results show that as the backbone disorder strength increases, the maximum current decreases for both sequences. However, the threshold voltage can increase or decrease with increasing backbone disorder depending on the sequence. The transmission results show that the position of transmission peaks changed with backbone disorder strength. Comparison with previous published results using poly(dG)-poly(dC) sequence shows that in contrast to that sequence, backbone disorder can decrease the threshold voltage in one of the sequences studied. This may point to a new understanding of the interplay between environmental and sequence disorder effect on charge transport in DNA.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
EditorsMitra Djamal, Nandang Mufti, Markus Diantoro
PublisherAmerican Institute of Physics Inc.
Pages22-25
Number of pages4
ISBN (Electronic)9780735412545
DOIs
Publication statusPublished - 1 Jan 2014
Event3rd International Conference on Theoretical and Applied Physics 2013, ICTAP 2013 - Malang, East Java, Indonesia
Duration: 10 Oct 201311 Oct 2013

Publication series

NameAIP Conference Proceedings
Volume1617
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Theoretical and Applied Physics 2013, ICTAP 2013
CountryIndonesia
CityMalang, East Java
Period10/10/1311/10/13

Keywords

  • backbone disorder
  • charge transport
  • DNA
  • I-V characteristics
  • sequence disorder
  • transmission

Fingerprint Dive into the research topics of 'Effect of medium on charge transport properties of modified poly(dA)-poly(dT) DNA molecular wire'. Together they form a unique fingerprint.

  • Cite this

    Suhendro, D. K., Yudiarsah, E., & Saleh, R. (2014). Effect of medium on charge transport properties of modified poly(dA)-poly(dT) DNA molecular wire. In M. Djamal, N. Mufti, & M. Diantoro (Eds.), AIP Conference Proceedings (pp. 22-25). (AIP Conference Proceedings; Vol. 1617). American Institute of Physics Inc.. https://doi.org/10.1063/1.4897095