TY - JOUR
T1 - Effect of losartan and enalapril on renal adaptation to sodium restriction in rat
AU - Jover, Bernakd
AU - Saladini, Dominique
AU - Nafrialdi, Nafrialdi
AU - Dupont, Madeleine
AU - Mimran, Albert
PY - 1994
Y1 - 1994
N2 - The influence of losartan (10 or 30 mg · kg-1 · day-1), enalapril (10 mg · kg-1 · day-1), and combined treatment by losartan and enalapril on the renal adaptation to dietary sodium withdrawal was assessed in normal rats. Treatments were given by gavage for 3 days before and during the 6-day period of low-sodium (LS) diet. Cumulative sodium excretion during LS was similar in untreated and low- dose losartan groups (0.62 ± 0.07 and 0.75 ± 0.07 mmol/6 days), whereas it was significantly increased in groups treated by the high dose of losartan and enalapril alone or combined with both doses of losartan (1.38 ± 0.16, 1.50 ± 0.10, 1.37 ± 0.16, and 1.12 ± 0.03 mmol/6 days, respectively). A decrease in conscious systolic arterial pressure was observed in all treated groups in response to LS. At the end of LS, conscious renal blood flow (microsphere method) was similarly increased in all treated groups. Creatinine clearance decreased to a similar extent with both doses of losartan, whereas a further reduction was observed with enalapril given alone or combined with losartan. These results demonstrate that the enalapril induced disturbance in the response of renal sodium excretion to LS is mainly related to angiotensin-mediated mechanisms. However, non-angiotensin-related actions of enalapril may contribute to the deterioration of renal function in sodium-restricted animals. In addition, a high dose of losartan is required to impair renal sodium conservation, thus suggesting that the tubular renin-angiotensin system may play a crucial role in the renal adaptation to dietary sodium withdrawal.
AB - The influence of losartan (10 or 30 mg · kg-1 · day-1), enalapril (10 mg · kg-1 · day-1), and combined treatment by losartan and enalapril on the renal adaptation to dietary sodium withdrawal was assessed in normal rats. Treatments were given by gavage for 3 days before and during the 6-day period of low-sodium (LS) diet. Cumulative sodium excretion during LS was similar in untreated and low- dose losartan groups (0.62 ± 0.07 and 0.75 ± 0.07 mmol/6 days), whereas it was significantly increased in groups treated by the high dose of losartan and enalapril alone or combined with both doses of losartan (1.38 ± 0.16, 1.50 ± 0.10, 1.37 ± 0.16, and 1.12 ± 0.03 mmol/6 days, respectively). A decrease in conscious systolic arterial pressure was observed in all treated groups in response to LS. At the end of LS, conscious renal blood flow (microsphere method) was similarly increased in all treated groups. Creatinine clearance decreased to a similar extent with both doses of losartan, whereas a further reduction was observed with enalapril given alone or combined with losartan. These results demonstrate that the enalapril induced disturbance in the response of renal sodium excretion to LS is mainly related to angiotensin-mediated mechanisms. However, non-angiotensin-related actions of enalapril may contribute to the deterioration of renal function in sodium-restricted animals. In addition, a high dose of losartan is required to impair renal sodium conservation, thus suggesting that the tubular renin-angiotensin system may play a crucial role in the renal adaptation to dietary sodium withdrawal.
KW - angiotensin receptor antagonist
KW - arterial pressure
KW - converting enzyme inhibitor
KW - dietary sodium restriction
KW - renin-angiotensin system
KW - sodium excretion
UR - http://www.scopus.com/inward/record.url?scp=0027935255&partnerID=8YFLogxK
U2 - 10.1152/ajprenal.1994.267.2.f281
DO - 10.1152/ajprenal.1994.267.2.f281
M3 - Article
C2 - 8067389
AN - SCOPUS:0027935255
SN - 0363-6127
VL - 267
SP - F281-F288
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 2
ER -