Effect of inhaled procaterol and budesonide on right ventricular diastolic function in children with asthma

Alit Utamayasa, Najib Advani, Imam Boediman, Sudigdo Sastroasmoro, Bambang Madiyono

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Abstract

Objectives To study changes in parameters of right ventricular (RV) diastolic function after procaterol and budesonide inhalation in children with asthma. Methods This was a one-group pretest-posttest design to determine changes in right ventricular diastolic function following four weeks of inhaled procaterol and budesonide administration. Subjects were children aged 8 to 18 years with frequent episodic asthma recruited consecutively at the Department of Child Health, Cipto Mangunkusumo Hospital. M-mode and 2-D echocardiography examinations were performed to determine RV isovolumetric relaxation time (IVRT), acceleration time (AT), deceleration time (DT), E wave, A wave, E/ A ratio, and tricuspid annular plane systolic excursion (TAPSE). Means of the RV function parameters before and after treatment were compared using the paired t-test or Wilcoxon test. Results There were 29 patients comprising 16 boys and 13 girls. The means or medians of theE wave, A wave, E/A ratio, acceleration time (AT), deceleration time (DT), and isovolumetric relaxation time (IVRT) before and after treatment were 0.55 and 0.55 em/sec (P=0.709), 0.45 and 0.35 em/sec (P<O.OOOl), 1.17 and 1.58 em/sec (P<0.0001), 52.73 and 55.03 m/sec (P=0.04), 55.39 and 58.10 m/ sec (P=0.03), and 46.50 and 70.0 m/sec (P<0.0001), respectively. The median pre- and post-inhalation TAPSE were 1.63 and 1.84 em, respectively (P<0.001). Conclusions In children with frequent episodic asthma, there are changes in RV diastolic functions IVRT, AT, DT, E/A ratio and A wave following procaterol and budesonide inhalation. There was no increase in E wave following inhalation. TAPSE was increased following procaterol and budesonide inhalation.
Original languageEnglish
JournalPaediatrica Indonesiana
Volume49
Issue number3
DOIs
Publication statusPublished - 2009

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