Effect of Hypobaric Hypoxia Induction on Cognitive Function and Glutamate Receptor in Sprague-Dawley Rats

Fanny Septiani Farhan, Angelina Fr Masengi, Margaretha Herawati, Wawan Mulyawan, Sri Widia A. Jusman, Mohamad Sadikin

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Abstract

Induction of sublethal hypoxia provides neuroprotective effect pathological processes such as myocardial infarc and stroke. This study aimed to know the effect of intermittent hypobaric hypoxia (IHH) induction on cognitive function and glutamate receptor in the rat brain. The study was conducted at dr. Saryanto Institute for Aviation and Aerospace Health (LAKESPRA) from 2015-2016. 25 sprague dawley rats, divided into 4 IHH treatment groups and 1 control group. Group 1 was induced with 1x IHH exposure, group 2 was induced with 2x IHH exposure, group 3 was induced with 3x IHH exposure and group 4 was induced with 4x IHH exposure (days 1, 8, 15 and 22). After induction, cognitive function tests are performed with Y Maze and immunohistochemistry is performed to evaluate the glutamate receptor N-methyl-D-aspartic acid (NMDA). There were no significant differences between the four treatment groups compared with the control group (p>0.05) on cognitif function, but significant difference in NMDA receptor. In conclution, HHI induction was not cause change cognitive fuction but increased the response of neuroplasticity of sprague-dawley rats brain tissue which assessed from increasing NMDA receptor.
Original languageEnglish
JournaleJournal Kedokteran Indonesia
Volume6
Issue number3
DOIs
Publication statusPublished - 2018

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