Effect of hyperglycemia at admission on the outcome of surgical evacuation of supratentorial spontaneous intracerebral hemorrhage

Introduction: Spontaneous intracerebral hemorrhage (SICH) has a high mortality rate. Factors that affect outcomes include hematoma volume and hyperglycemia. Evacuation of hematoma reduces mortality. This study aimed to validate the effect of hyperglycemia at admission on the outcome of surgical evacuation of supratentorial SICH. Methods: This study is part of a clinical trial that assessed the neuroprotective effects of tigecycline. The association between patient variables and in-hospital mortality and length of hospital stay (LOS) was analyzed using the chi-square test and Fisher’s exact test. Logistic regression was conducted to identify the independent predictors of outcome. Results: Approximately 65% of patients with supratentorial SICH were hyperglycaemic. The factors associated with hyperglycaemia were brain midline shift (MLS) (odds ratio [OR]: 14.5; 95% confidence interval [CI]: 1.8 – 117.3; p = 0.002) and history of diabetes (OR: 7.7; 95% CI: 0.9 – 63.6; p = 0.045). Hyperglycaemia was a predictor of MLS (OR: 0.074, 95% CI: 0.009 – 0.613; p = 0.016) and was not significantly associated with in-hospital mortality (OR: 2.6; 95% CI: 0.7 – 8.9; p = 0.126) and LOS > 15 days (OR: 0.9; 95% CI: 0.3 – 2.7; p = 0.898). Conclusion: Hyperglycemia was not associated with in-hospital mortality and LOS in patients with supratentorial SICH.