Objective: We determined the effectiveness of honey propolis hard candy on salivary lactoperoxidase activity in unstimulated saliva. Methods: In this pretest-posttest laboratory experimental design study, saliva collected from 120 subjects was reacted with potassium iodide, phosphate buffer, and hydrogen peroxide. Salivary lactoperoxidase activity was calculated by absorbance value using a microplate reader at wavelength of 340 nm. Results: Honey propolis hard candy increased salivary lactoperoxidase activity, although the increase was not statistically significant (p>0.05). Conclusions: Honey propolis hard candy tends to increase salivary lactoperoxidase activity.