Polylactic acid (PLA) nanoparticles could provide extended release of drugs, reducing the frequency of injection and increasing the compliance diabetic retinopathy patients. This requires nanoparticles with a mean diameter of approximately 200 nm to facilitate penetration of small and narrow blood vessels in the retina. Mean diameter of PLA particles prepared using the emulsification-evaporation method was found to depend linearly on the speed of the high speed homogenizer, based on the data taken in the range of 1,000-10,000 rpm. PLA nanoparticles with a mean particle diameter of 190 nm with a spherical morphology could be obtained using a homogenizer speed of 10,000 rpm, allowing the use of PLA nanoparticles for extended release of drugs in the retina.
|Journal of Physics: Conference Series
|Published - 10 May 2019
|1st Symposium of Emerging Nuclear Technology and Engineering Novelty, SENTEN 2018 - Palembang, South Sumatra, India
Duration: 4 Jul 2018 → 5 Jul 2018
- high speed homogenizer
- Particle size
- polylactic acid