Effect of high speed homogenizer speed on particle size of polylactic acid

K. Mulia, A. Safiera, I. F. Pane, E. A. Krisanti

Research output: Contribution to journalConference articlepeer-review

3 Citations (Scopus)

Abstract

Polylactic acid (PLA) nanoparticles could provide extended release of drugs, reducing the frequency of injection and increasing the compliance diabetic retinopathy patients. This requires nanoparticles with a mean diameter of approximately 200 nm to facilitate penetration of small and narrow blood vessels in the retina. Mean diameter of PLA particles prepared using the emulsification-evaporation method was found to depend linearly on the speed of the high speed homogenizer, based on the data taken in the range of 1,000-10,000 rpm. PLA nanoparticles with a mean particle diameter of 190 nm with a spherical morphology could be obtained using a homogenizer speed of 10,000 rpm, allowing the use of PLA nanoparticles for extended release of drugs in the retina.

Original languageEnglish
Article number062006
JournalJournal of Physics: Conference Series
Volume1198
Issue number6
DOIs
Publication statusPublished - 10 May 2019
Event1st Symposium of Emerging Nuclear Technology and Engineering Novelty, SENTEN 2018 - Palembang, South Sumatra, India
Duration: 4 Jul 20185 Jul 2018

Keywords

  • high speed homogenizer
  • Particle size
  • polylactic acid

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