TY - GEN
T1 - Effect of hibiscus sabdariffa linn. On oxidative stress in cardiac tissue of overtrained rat
T2 - 16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019
AU - Paramita, Nurul
AU - Fatayati, Imma
AU - Dewi, Syarifah
AU - Santoso, Dewi Irawati Soeria
AU - Andraini, Trinovita
AU - Kartinah, Neng Tine
AU - Ilyas, Ermita Isfandiary Ibrahim
AU - Qibtiyah, Mariyal
AU - Yunita, Sri
N1 - Funding Information:
This study was funded by Hibah PITTA Universitas Indonesia 2018.We would like to thank everyone who support the preparation of this paper.
Publisher Copyright:
© 2020 Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/4
Y1 - 2020/5/4
N2 - Accumulation of overtraining/OT volume, in the long run can lead to decreased performance called overtraining syndrome (OTS). Oxidative stress, an imbalance state of endogenous antioxidants and free radicals, is closely related to pathophysiology of OTS and in the long run can cause cardiovascular disorders. Some research shows that oxidative stress can be inhibited through antioxidants supplementation. Hibiscus Sabdariffa Linn. (H. sabdariffa) is a plant that contains high antioxidants. This study aims to explore the effect of OT on oxidative stress level in rat's cardiac tissue and the effect of H. Sabdariffa supplementation to the level of oxidative stress in OT rats. The study was an experimental study using 25 adult Wistar rats, 8-10 weeks, 290-390 gr, randomized into five groups: Control (C), Control + Hibiscus (C-Hib), Aerobic Exercise (A), Overtraining (OT) and Overtraining + Hibiscus (OT-Hib). Dosage of H. sabdariffa given: 500 mg / kg / day. Aerobic physical exercise was given 2 x/wk, 10 min, 12 m/min, lasted for 11 wks. Overtraining protocols was given 5x/wk with increasing frequency and decreasing recovery time between sessions for 11 wks. Calculated levels of MDA, SOD and GSH using spectrophotometry and Nox2 using ELISA at the end of Week 11. The result showed that overtraining induces an oxidative stress condition in the rat's cardiac tissue characterized by higher MDA levels than aerobic and control rats, and lower GSH levels than aerobic rats. The administration of H. sabdariffa may induce oxidative stress reduction in overtraining rat's cardiac tissue, characterized by lower MDA levels and higher GSH levels in overtraining rats given H. sabdariffa compared to overtraining rats.
AB - Accumulation of overtraining/OT volume, in the long run can lead to decreased performance called overtraining syndrome (OTS). Oxidative stress, an imbalance state of endogenous antioxidants and free radicals, is closely related to pathophysiology of OTS and in the long run can cause cardiovascular disorders. Some research shows that oxidative stress can be inhibited through antioxidants supplementation. Hibiscus Sabdariffa Linn. (H. sabdariffa) is a plant that contains high antioxidants. This study aims to explore the effect of OT on oxidative stress level in rat's cardiac tissue and the effect of H. Sabdariffa supplementation to the level of oxidative stress in OT rats. The study was an experimental study using 25 adult Wistar rats, 8-10 weeks, 290-390 gr, randomized into five groups: Control (C), Control + Hibiscus (C-Hib), Aerobic Exercise (A), Overtraining (OT) and Overtraining + Hibiscus (OT-Hib). Dosage of H. sabdariffa given: 500 mg / kg / day. Aerobic physical exercise was given 2 x/wk, 10 min, 12 m/min, lasted for 11 wks. Overtraining protocols was given 5x/wk with increasing frequency and decreasing recovery time between sessions for 11 wks. Calculated levels of MDA, SOD and GSH using spectrophotometry and Nox2 using ELISA at the end of Week 11. The result showed that overtraining induces an oxidative stress condition in the rat's cardiac tissue characterized by higher MDA levels than aerobic and control rats, and lower GSH levels than aerobic rats. The administration of H. sabdariffa may induce oxidative stress reduction in overtraining rat's cardiac tissue, characterized by lower MDA levels and higher GSH levels in overtraining rats given H. sabdariffa compared to overtraining rats.
UR - http://www.scopus.com/inward/record.url?scp=85096433419&partnerID=8YFLogxK
U2 - 10.1063/5.0006534
DO - 10.1063/5.0006534
M3 - Conference contribution
AN - SCOPUS:85096433419
T3 - AIP Conference Proceedings
BT - Recent Progress on
A2 - Yuliusman, Yuliusman
A2 - Dianita, Cindy
PB - American Institute of Physics Inc.
Y2 - 22 July 2019 through 24 July 2019
ER -