Effect of hibiscus sabdariffa linn on IL-6 and TNF-α levels in overtrained rat heart

Dewi Irawati Soeria Santoso; Sri Yunita; Nurul Paramita; Trinovita Andraini; Neng Tine Kartinah; Gushan Fahmi El Bayani; Ermita I.Ibrahim Ilyas

doi:10.22159/ijap.2019.v11s6.33535

Effect of hibiscus sabdariffa linn on IL-6 and TNF-α levels in overtrained rat heart

Dewi Irawati Soeria Santoso
, Sri Yunita
, Nurul Paramita
, Trinovita Andraini
, Neng Tine Kartinah
, Gushan Fahmi El Bayani
, Ermita I.Ibrahim Ilyas

Department of Physiology Pre Clinic

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: This study aims to determine the effect of Hibiscus sabdariffa Linn. (HSL) administration on the interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels in rat heart. Overtraining was proven to increase the IL-6 and TNF-α levels in the blood, and HSL had anti-inflammatory and anti-oxidant properties. However, no studies have been conducted on the effect of methanolic extract of HSL administration on the IL-6 and TNF-α levels in overtrained rat heart. Methods: This study used 25 male adult Wistar rats aged 8–10 w and weighing 200–250 g. The rats were randomly divided into five groups: Control (C), control H. sabdariffa Linn (C+HSL), overtraining (OT), overtraining H. sabdariffa Linn (OT+HSL), and aerobic (A). Treatment was given 5 times a week for 11 w. At the end of the study, the IL-6 and TNF-α levels were measured using a standard ELISA kit. Results: IL-6 and TNF-α levels in the heart were the highest in the overtraining group. The group that received HSL administration showed the lowest TNF-α and IL-6 levels. Conclusion: HSL could be a used to protect the heart from an inflammatory state, particularly in an overtraining condition.

Original language	English
Pages (from-to)	42-45
Number of pages	4
Journal	International Journal of Applied Pharmaceutics
Volume	11
Issue number	Special Issue 6
DOIs	https://doi.org/10.22159/ijap.2019.v11s6.33535
Publication status	Published - Nov 2019

Keywords

Hibiscus sabdariffa Linn
Interleukin-6
Overtraining
Tumor Necrosis Factor-alpha

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10.22159/ijap.2019.v11s6.33535

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title = "Effect of hibiscus sabdariffa linn on IL-6 and TNF-α levels in overtrained rat heart",

abstract = "Objective: This study aims to determine the effect of Hibiscus sabdariffa Linn. (HSL) administration on the interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels in rat heart. Overtraining was proven to increase the IL-6 and TNF-α levels in the blood, and HSL had anti-inflammatory and anti-oxidant properties. However, no studies have been conducted on the effect of methanolic extract of HSL administration on the IL-6 and TNF-α levels in overtrained rat heart. Methods: This study used 25 male adult Wistar rats aged 8–10 w and weighing 200–250 g. The rats were randomly divided into five groups: Control (C), control H. sabdariffa Linn (C+HSL), overtraining (OT), overtraining H. sabdariffa Linn (OT+HSL), and aerobic (A). Treatment was given 5 times a week for 11 w. At the end of the study, the IL-6 and TNF-α levels were measured using a standard ELISA kit. Results: IL-6 and TNF-α levels in the heart were the highest in the overtraining group. The group that received HSL administration showed the lowest TNF-α and IL-6 levels. Conclusion: HSL could be a used to protect the heart from an inflammatory state, particularly in an overtraining condition.",

keywords = "Hibiscus sabdariffa Linn, Interleukin-6, Overtraining, Tumor Necrosis Factor-alpha",

author = "Santoso, \{Dewi Irawati Soeria\} and Sri Yunita and Nurul Paramita and Trinovita Andraini and Kartinah, \{Neng Tine\} and \{El Bayani\}, \{Gushan Fahmi\} and Ilyas, \{Ermita I.Ibrahim\}",

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year = "2019",

month = nov,

doi = "10.22159/ijap.2019.v11s6.33535",

language = "English",

volume = "11",

pages = "42--45",

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T1 - Effect of hibiscus sabdariffa linn on IL-6 and TNF-α levels in overtrained rat heart

AU - Santoso, Dewi Irawati Soeria

AU - Yunita, Sri

AU - Paramita, Nurul

AU - Andraini, Trinovita

AU - Kartinah, Neng Tine

AU - El Bayani, Gushan Fahmi

AU - Ilyas, Ermita I.Ibrahim

PY - 2019/11

Y1 - 2019/11

N2 - Objective: This study aims to determine the effect of Hibiscus sabdariffa Linn. (HSL) administration on the interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels in rat heart. Overtraining was proven to increase the IL-6 and TNF-α levels in the blood, and HSL had anti-inflammatory and anti-oxidant properties. However, no studies have been conducted on the effect of methanolic extract of HSL administration on the IL-6 and TNF-α levels in overtrained rat heart. Methods: This study used 25 male adult Wistar rats aged 8–10 w and weighing 200–250 g. The rats were randomly divided into five groups: Control (C), control H. sabdariffa Linn (C+HSL), overtraining (OT), overtraining H. sabdariffa Linn (OT+HSL), and aerobic (A). Treatment was given 5 times a week for 11 w. At the end of the study, the IL-6 and TNF-α levels were measured using a standard ELISA kit. Results: IL-6 and TNF-α levels in the heart were the highest in the overtraining group. The group that received HSL administration showed the lowest TNF-α and IL-6 levels. Conclusion: HSL could be a used to protect the heart from an inflammatory state, particularly in an overtraining condition.

AB - Objective: This study aims to determine the effect of Hibiscus sabdariffa Linn. (HSL) administration on the interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels in rat heart. Overtraining was proven to increase the IL-6 and TNF-α levels in the blood, and HSL had anti-inflammatory and anti-oxidant properties. However, no studies have been conducted on the effect of methanolic extract of HSL administration on the IL-6 and TNF-α levels in overtrained rat heart. Methods: This study used 25 male adult Wistar rats aged 8–10 w and weighing 200–250 g. The rats were randomly divided into five groups: Control (C), control H. sabdariffa Linn (C+HSL), overtraining (OT), overtraining H. sabdariffa Linn (OT+HSL), and aerobic (A). Treatment was given 5 times a week for 11 w. At the end of the study, the IL-6 and TNF-α levels were measured using a standard ELISA kit. Results: IL-6 and TNF-α levels in the heart were the highest in the overtraining group. The group that received HSL administration showed the lowest TNF-α and IL-6 levels. Conclusion: HSL could be a used to protect the heart from an inflammatory state, particularly in an overtraining condition.

KW - Hibiscus sabdariffa Linn

KW - Interleukin-6

KW - Overtraining

KW - Tumor Necrosis Factor-alpha

UR - https://www.scopus.com/pages/publications/85077081586

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DO - 10.22159/ijap.2019.v11s6.33535

M3 - Article

AN - SCOPUS:85077081586

SN - 0975-7058

VL - 11

SP - 42

EP - 45

JO - International Journal of Applied Pharmaceutics

JF - International Journal of Applied Pharmaceutics

IS - Special Issue 6

ER -

Effect of hibiscus sabdariffa linn on IL-6 and TNF-α levels in overtrained rat heart

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Keywords

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