Effect of freezing temperature in thermally induced phase separation method in hydroxyapatite/chitosan-based bone scaffold biomaterial

Muh Fadhil Albab, Akhmad Herman Yuwono, Nofrijon Bin Imam Sofyan, Ghiska Ramahdita

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In the current study, hydroxyapatite (HA)/chitosan-based bone scaffold has been fabricated using Thermally Induced Phase Separation (TIPS) method under freezing temperature variation of -20, -30, -40 and -80°C. The samples with weight percent ratio of 70% HA and 30% chitosan were homogeneously mixed and subsequently dissolved in 2% acetic acid. The synthesized samples were further characterized using Fourier transform infrared (FTIR), compressive test and scanning electron microscope (SEM). The investigation results showed that low freezing temperature reduced the pore size and increased the compressive strength of the scaffold. In the freezing temperature of -20°C, the pore size was 133.93 μm with the compressive strength of 5.9 KPa, while for -80°C, the pore size declined to 60.55 μm with the compressive strength 29.8 KPa. Considering the obtained characteristics, HA/chitosan obtained in this work has potential to be applied as a bone scaffold.

Original languageEnglish
Title of host publicationBiomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 1st International Symposium of Biomedical Engineering, ISBE 2016
EditorsYudan Whulanza, Sugeng Supriadi, Muhamad Sahlan, Basari
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735414853
DOIs
Publication statusPublished - 21 Feb 2017
Event1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016 - Depok City, Indonesia
Duration: 31 May 20161 Jun 2016

Publication series

NameAIP Conference Proceedings
Volume1817
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016
CountryIndonesia
CityDepok City
Period31/05/161/06/16

Keywords

  • chitosan
  • hydroxyapatite
  • scaffold
  • Thermally Induced Phase Separation

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  • Cite this

    Albab, M. F., Yuwono, A. H., Sofyan, N. B. I., & Ramahdita, G. (2017). Effect of freezing temperature in thermally induced phase separation method in hydroxyapatite/chitosan-based bone scaffold biomaterial. In Y. Whulanza, S. Supriadi, M. Sahlan, & Basari (Eds.), Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the 1st International Symposium of Biomedical Engineering, ISBE 2016 [020007] (AIP Conference Proceedings; Vol. 1817). American Institute of Physics Inc.. https://doi.org/10.1063/1.4976759