Global warming that occurred over the last century led to the increase in surface temperature of the earth. The increase of the temperature affects the physiological adaptations of the organism. Bali cattle (Bos sondaicus) is one of the native Indonesian cattle that have high adaptability in response to the changing of environmental conditions, such as the increase of temperature. The aim of this study is to understand the correlation between environmental conditions and physiological response of Bali cattle in Bogor district and West Sumbawa district. Environmental parameters from each location, which consist of air temperature, solar radiation, wind speed, and relative humidity, were measured every hour. Physiological profiles such as body temperature, skin temperature, rectal temperature, and respiration rate within one minute were measured for five days in August 2016. The statistical analysis with Pearson Correlation test (p<0.05) showed that the physiological profiles of Bali cattle in Bogor district was affected by air temperature, relative humidity, wind speed, and solar radiation, while the physiological profiles of Bali cattle in West Sumbawa district was affected by air temperature and wind speed. This result indicated that environmental conditions affect the physiological response of Bali cattle in both districts and Bali cattle have good adaptability to response the changing of environmental conditions.