Effect of electroacupuncture combined with medical treatment on insulin resistance (HOMA-IR) of patients with metabolic syndrome

Metabolic syndrome is a complex disorder defined by a cluster of interconnected factors that increase the risk of cardiovascular diseases and diabetes mellitus type 2. Insulin resistance and central obesity are considered to be significant factors and underlying causes of metabolic syndrome; therefore, a reduction in insulin resistance is an important clinical goal. Studies have concluded that acupuncture can improve insulin sensitivity because it is effective against metabolic disturbances. A single-blind randomized controlled trial was conducted involving 50 patients who were randomly allocated into two groups: the electroacupuncture with medication group (n = 25) and sham electroacupuncture with medication group (n = 25). Electroacupuncture therapy was given twice a week for 10 times at points CV12 Zhongwan, CV4 Guanyuan, ST25 Tianshu, ST36 Zusanli, ST40 Fenglong, SP6 Sanyinjiao, and MA-IC3 Endocrine. Fasting blood glucose and fasting insulin serum levels were assessed according to the homeostasis model assessment of insulin resistance (HOMA-IR) as the primary outcome. There was a statistically significant difference in HOMA-IR changes between the electroacupuncture with medication group and sham electroacupuncture with medication group (-1.66 ± 2.187 and -0.29 ± 2.388, respectively; p = 0.044). Electroacupuncture with medical treatment effectively decreased insulin resistance of patients with metabolic syndrome.