TY - GEN
T1 - Effect of drug loading method on drug dissolution mechanism of amoxicillin trihydrate encapsulated in chitosan-poly(N-vinylpyrrolidone) full-ipn hydrogel as a floating drug delivery system matrix
AU - Baihaqi, Ahmad Ichsan
AU - Rahayu, Dyah Utami Cahyaning
AU - Budianto, Emil
N1 - Funding Information:
The Authors would like to thank Directorate of Research and Community Engagement (DRPM) Universitas Indonesia for supporting our research financially through Hibah Publikasi Internasional Terindeks untuk Tugas Akhir (Hibah PITTA) 2017. We also would like to thank Department of Chemistry and Institute for Advancement of Science Technology and Humanity (IASTH), Universitas Indonesia for supporting us and providing the instrumental facilities for our research. Emil Budianto and Dyah Utami Cahyaning Rahayu as the supervisor in this research and designed the research pipeline, while Ahmad Ichsan Baihaqi conducted the experimental details, analyzed the data and wrote the final manuscript. Herewith, we would declare that there is no conflict of interest regarding this manuscript.
Publisher Copyright:
© 2019 Trans Tech Publications Ltd, Switzerland.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Amoxicillin trihydrate suits to be encapsulated into a modified matrix to increase its bioavailability. In this study, the effect of drug loading methods on drug dissolution mechanism from chitosan-poly(N-vinylpyrrolidone) hydrogel with CaCO3 as the effervescent agent has been studied. It was found that the encapsulation efficiency of in situ and post loading methods were 93% and 75%, respectively. The dissolution values were 94% and 98%, respectively for in situ and post loading. The dissolution test data was incorporated into zero-order, first-order, Higuchi and Korsmeyer-Peppas models to evaluate the kinetic and the mechanism of the drug dissolutions. The in situ loading method fits well to first-order model (R2 = 0.9772), while the post loading method fits well to Higuchi model (R2 = 0.9880). Based on Korsmeyer-Peppas model, the dissolution mechanism of in situ loading was Fickian diffusion (n = 0.4024), while post loading was a combination of diffusion and erosion (n = 0.5532). From the SEM images, it showed that the surface and cross-sectional of the post loading method hydrogel formed pores and pore channels, both before and after the dissolution test. Meanwhile, on the surface and the cross-sectional of in situ loading method hydrogel had pores and pore channels only after dissolution test.
AB - Amoxicillin trihydrate suits to be encapsulated into a modified matrix to increase its bioavailability. In this study, the effect of drug loading methods on drug dissolution mechanism from chitosan-poly(N-vinylpyrrolidone) hydrogel with CaCO3 as the effervescent agent has been studied. It was found that the encapsulation efficiency of in situ and post loading methods were 93% and 75%, respectively. The dissolution values were 94% and 98%, respectively for in situ and post loading. The dissolution test data was incorporated into zero-order, first-order, Higuchi and Korsmeyer-Peppas models to evaluate the kinetic and the mechanism of the drug dissolutions. The in situ loading method fits well to first-order model (R2 = 0.9772), while the post loading method fits well to Higuchi model (R2 = 0.9880). Based on Korsmeyer-Peppas model, the dissolution mechanism of in situ loading was Fickian diffusion (n = 0.4024), while post loading was a combination of diffusion and erosion (n = 0.5532). From the SEM images, it showed that the surface and cross-sectional of the post loading method hydrogel formed pores and pore channels, both before and after the dissolution test. Meanwhile, on the surface and the cross-sectional of in situ loading method hydrogel had pores and pore channels only after dissolution test.
KW - Amoxicillin Trihydrate
KW - Chitosan
KW - Dissolution Mechanism
KW - Floating Drug Delivery System
KW - Hydrogel
UR - http://www.scopus.com/inward/record.url?scp=85071921113&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/MSF.964.251
DO - 10.4028/www.scientific.net/MSF.964.251
M3 - Conference contribution
AN - SCOPUS:85071921113
SN - 9783035714340
T3 - Materials Science Forum
SP - 251
EP - 256
BT - Seminar on Materials Science and Technology
A2 - Noerochim, Lukman
PB - Trans Tech Publications Ltd
T2 - 4th International Seminar on Science and Technology, ISST 2018
Y2 - 9 August 2018 through 9 August 2018
ER -