Effect of drug loading method on drug dissolution mechanism of amoxicillin trihydrate encapsulated in chitosan-poly(N-vinylpyrrolidone) full-ipn hydrogel as a floating drug delivery system matrix

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Abstract

Amoxicillin trihydrate suits to be encapsulated into a modified matrix to increase its bioavailability. In this study, the effect of drug loading methods on drug dissolution mechanism from chitosan-poly(N-vinylpyrrolidone) hydrogel with CaCO3 as the effervescent agent has been studied. It was found that the encapsulation efficiency of in situ and post loading methods were 93% and 75%, respectively. The dissolution values were 94% and 98%, respectively for in situ and post loading. The dissolution test data was incorporated into zero-order, first-order, Higuchi and Korsmeyer-Peppas models to evaluate the kinetic and the mechanism of the drug dissolutions. The in situ loading method fits well to first-order model (R2 = 0.9772), while the post loading method fits well to Higuchi model (R2 = 0.9880). Based on Korsmeyer-Peppas model, the dissolution mechanism of in situ loading was Fickian diffusion (n = 0.4024), while post loading was a combination of diffusion and erosion (n = 0.5532). From the SEM images, it showed that the surface and cross-sectional of the post loading method hydrogel formed pores and pore channels, both before and after the dissolution test. Meanwhile, on the surface and the cross-sectional of in situ loading method hydrogel had pores and pore channels only after dissolution test.

Original languageEnglish
Title of host publicationSeminar on Materials Science and Technology
EditorsLukman Noerochim
PublisherTrans Tech Publications Ltd
Pages251-256
Number of pages6
ISBN (Print)9783035714340
DOIs
Publication statusPublished - 1 Jan 2019
Event4th International Seminar on Science and Technology, ISST 2018 - Surabaya, Indonesia
Duration: 9 Aug 20189 Aug 2018

Publication series

NameMaterials Science Forum
Volume964 MSF
ISSN (Print)0255-5476

Conference

Conference4th International Seminar on Science and Technology, ISST 2018
Country/TerritoryIndonesia
CitySurabaya
Period9/08/189/08/18

Keywords

  • Amoxicillin Trihydrate
  • Chitosan
  • Dissolution Mechanism
  • Floating Drug Delivery System
  • Hydrogel

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