TY - GEN
T1 - Effect of drug loading method against the dissolution mechanism of encapsulated amoxicillin trihidrate drug in matrix of semi-IPN chitosan-poly (N-vinyl pyrrolidone) hydrogel with pore forming agent CaCO3
AU - Nurjannah, Yanah
AU - Budianto, Emil
N1 - Funding Information:
The Authors would like to thank Directorate of Research and Community Engagement (DRPM) Universitas Indonesia for supporting our research financially through Hibah Publikasi Internasional Terindeks untuk Tugas Akhir (Hibah PITTA) 2017. We also would like to thank Department of Chemistry and Institute for Advancement of Science Technology and Humanity (IASTH), Universitas Indonesia for supporting us and providing the instrumental facilities for our research. Emil Budianto as the supervisor in this research and designed the research pipeline, while Yanah Nurjannah conducted the experimental details, analyzed the data and wrote the final manuscript. Herewith, we would declare that there is no conflict of interest regarding this manuscript.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Heliobacter pylori (H.pylori) is a type of bacteria that causes inflammation in the lining of the stomach. The treatment of the bacterial infection by using conventional medicine which is amoxicillin trihidrate has a very short retention time in the stomach which is about 1-1,5 hours. Floating drug delivery system is expected to have a long retention time in the stomach so the efficiency of drug can be achieved. In this study, has been synthesized matrix of semi-IPN chitosan-Poly(N-vinil pyrrolidone) hydrogel with a pore-forming agent of CaCO3 under optimum conditions. Amoxicillin is encapsulated in a matrix hydrogel to be applied as a floating drug delivery system by in situ loading and post loading methods. The encapsulation efficiency and dissolution of in situ loading and post loading hydrogels are performed in vitro on gastric pH. In situ loading hydrogel shows higer percentage of encapsulation efficiency and dissolution compared to post loading hydrogel. The encapsulation efficiency of in situ and post loading hydrogels were 92,1% and 89,4%, respectively. The aim of drug dissolution by mathematical equation model is to know kinetics and the mecanism of dissolution. The kinetics release of in situ hydrogel tends to follow first order kinetics, while the post loading hydrogel follow the Higuchi model. The dissolution mecanism of hydrogels is erosion.
AB - Heliobacter pylori (H.pylori) is a type of bacteria that causes inflammation in the lining of the stomach. The treatment of the bacterial infection by using conventional medicine which is amoxicillin trihidrate has a very short retention time in the stomach which is about 1-1,5 hours. Floating drug delivery system is expected to have a long retention time in the stomach so the efficiency of drug can be achieved. In this study, has been synthesized matrix of semi-IPN chitosan-Poly(N-vinil pyrrolidone) hydrogel with a pore-forming agent of CaCO3 under optimum conditions. Amoxicillin is encapsulated in a matrix hydrogel to be applied as a floating drug delivery system by in situ loading and post loading methods. The encapsulation efficiency and dissolution of in situ loading and post loading hydrogels are performed in vitro on gastric pH. In situ loading hydrogel shows higer percentage of encapsulation efficiency and dissolution compared to post loading hydrogel. The encapsulation efficiency of in situ and post loading hydrogels were 92,1% and 89,4%, respectively. The aim of drug dissolution by mathematical equation model is to know kinetics and the mecanism of dissolution. The kinetics release of in situ hydrogel tends to follow first order kinetics, while the post loading hydrogel follow the Higuchi model. The dissolution mecanism of hydrogels is erosion.
KW - Hydrogel
KW - floating drug delivery system (FDDS)
KW - in situ loading hydrogel
KW - post loading hydrogel
KW - semi-IPN
UR - http://www.scopus.com/inward/record.url?scp=85045616241&partnerID=8YFLogxK
U2 - 10.1063/1.5030225
DO - 10.1063/1.5030225
M3 - Conference contribution
AN - SCOPUS:85045616241
T3 - AIP Conference Proceedings
BT - Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
A2 - Hidayat, Mas Irfan P.
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Y2 - 30 October 2017 through 31 October 2017
ER -