TY - GEN
T1 - Effect of drug loading method against drug dissolution mechanism of encapsulated amoxicillin trihydrate in matrix of semi-IPN chitosan-poly(N -vinylpyrrolidone) hydrogel with KHCO3 as pore forming agent in floating drug delivery system
AU - Fimantari, Khansa
AU - Budianto, Emil
N1 - Funding Information:
The Authors would like to thank Directorate of Research and Community Engagement (DRPM) Universitas Indonesia for supporting our research financially through Hibah Publikasi Internasional Terindeks untuk Tugas Akhir (Hibah PITTA) 2017. We also would like to thank Department of Chemistry and Institute for Advancement of Science Technology and Humanity (IASTH), Universitas Indonesia for supporting us and providingthe instrumental facilities for our research. Emil Budianto as the supervisor in this research and designed the research pipeline, while Khansa Fimantari conducted the experimental details, analyzed the data and wrote the final manuscript. Herewith, we would declare that there is no conflict of interest regarding this manuscript.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Helicobacterpylori infection can be treated using trihydrate amoxicillin. However, this treatment is not effective enough, as the conventional dosage treatment has a relatively short retention time in the human stomach. In the present study, the amoxicillin trihydrate drug will be encapsulated into a semi-IPN K-PNVP hydrogel matrix with 7,5% KHCO3 as a pore-forming agent. The encapsulated drug is tested with in vitro method to see the efficiency of its encapsulation and dissolution. The hydrogel in situ loading produces an encapsulation efficiency value. The values of the encapsulation efficiency are 95% and 98%, while post loading hydrogel yields an encapsulation efficiency value is 77% and the dissolution is 84%. The study of drug dissolution mechanism was done by using mathematical equation model to know its kinetics and its mechanism of dissolution. The post loading hydrogel was done by using thefirst-order model, while hydrogel in situ loading used Higuchi model. The Korsmeyer-Peppas model shows that post loading hydrogel dissolution mechanism is a mixture of diffusion and erosion, and in situ loading hydrogel in the form of diffusion. It is supported by the results of hydrogel characterization, before and after dissolution test with an optical microscope. The results of the optical microscope show that the hydrogel surface before and after the dissolution tested for both methods shows the change becomes rougher.
AB - Helicobacterpylori infection can be treated using trihydrate amoxicillin. However, this treatment is not effective enough, as the conventional dosage treatment has a relatively short retention time in the human stomach. In the present study, the amoxicillin trihydrate drug will be encapsulated into a semi-IPN K-PNVP hydrogel matrix with 7,5% KHCO3 as a pore-forming agent. The encapsulated drug is tested with in vitro method to see the efficiency of its encapsulation and dissolution. The hydrogel in situ loading produces an encapsulation efficiency value. The values of the encapsulation efficiency are 95% and 98%, while post loading hydrogel yields an encapsulation efficiency value is 77% and the dissolution is 84%. The study of drug dissolution mechanism was done by using mathematical equation model to know its kinetics and its mechanism of dissolution. The post loading hydrogel was done by using thefirst-order model, while hydrogel in situ loading used Higuchi model. The Korsmeyer-Peppas model shows that post loading hydrogel dissolution mechanism is a mixture of diffusion and erosion, and in situ loading hydrogel in the form of diffusion. It is supported by the results of hydrogel characterization, before and after dissolution test with an optical microscope. The results of the optical microscope show that the hydrogel surface before and after the dissolution tested for both methods shows the change becomes rougher.
KW - Hydrogel
KW - chitosan
KW - dissolution mechanism
KW - floating drug delivery system (FDDS)
KW - poly(N-vinylpyrrolidone)
KW - pore forming agent
KW - potassium bicarbonate
KW - semi-IPN
UR - http://www.scopus.com/inward/record.url?scp=85045618871&partnerID=8YFLogxK
U2 - 10.1063/1.5030223
DO - 10.1063/1.5030223
M3 - Conference contribution
AN - SCOPUS:85045618871
T3 - AIP Conference Proceedings
BT - Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
A2 - Hidayat, Mas Irfan P.
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Y2 - 30 October 2017 through 31 October 2017
ER -