TY - GEN
T1 - Effect of different radiopharmaceutical drug to the performance of translation methods of TIACs from mice to human
AU - Anwari, M. Z.
AU - Humani, T. S.
AU - Hidayati, N. R.
AU - Hardiansyah, D.
N1 - Funding Information:
The author would like to thank to the Centre for Radioisotope and Radiopharmaceutical Technology, National Nuclear Energy of Indonesia, for pharmacokinetics data of 177Lu-DOTA-Trastuzumab used in this work. Also, This work was supported by the Department of Medical Physics and Biophysics, University of Indonesia (Hibah PUTI Prosiding, Grant Number: NKB-986/UN2.RST/HKP.05.00/2020) for this research and publication.
Funding Information:
work was supported by the Department of Medical Physics and Biophysics, University of Indonesia (Hibah PUTI Prosiding, Grant Number : NKB-986/UN2.RST/HKP.05.00/2020) for this research and publication.
Publisher Copyright:
© 2021 Author(s).
PY - 2021/3/29
Y1 - 2021/3/29
N2 - The aim of this study was to investigate the effect of different radiopharmaceutical drugs on the performance of translation method of time-integrated activity coefficient (TIAC) from mice to humans. 177Lu-DOTA-Trastuzumab (Tras) percentage of injected dose (%ID) in Swiss Webster mice at 1, 2, 3, 4, 24, and 48 hours p.i was used to fit the parameters of the five Sum of Exponential (SOE) functions. Goodness of fit criteria, i.e graph visualization, coefficient of variation (CV<50%), and Correlation Matrix (-0.8 ≤ CMi,j ≥ 0.8), and Akaike Information Criterion (AICc) were used to select the best function then the function was integrated to determine the TIACs value. Five translation methods, i.e. no scaling (NS), mass scaling (MS), time scaling (TS), time-mass scaling (TMS), and allometric scaling (AS) were used to translate the TIACs in mice to human for liver and kidneys. The relative deviations (RDs) of the predicted TIACs in humans from each translation method to the best translation method suggested in Beykan et al study, i.e. TS, were analyzed. The effects of the radiopharmaceutical drugs, i.e. Tras and JR11, to the performance of each translation method i were calculated as Δi=(RDiTras-RDiJR11). As a result, the Δ are 12%(NS); 2%(MS); 2,9%(TMS); and 3,3%(AS) for kidneys and 45,2%(NS); 13,4%(MS); 13,8%(TMS); and 23,5%(AS) for liver. In general, the Δ values are less than 15% except for the NS and AS methods in the liver. It concludes that each method yields totally different prediction from another methods that the best translation method is important for each radiopharmaceutical drugs.
AB - The aim of this study was to investigate the effect of different radiopharmaceutical drugs on the performance of translation method of time-integrated activity coefficient (TIAC) from mice to humans. 177Lu-DOTA-Trastuzumab (Tras) percentage of injected dose (%ID) in Swiss Webster mice at 1, 2, 3, 4, 24, and 48 hours p.i was used to fit the parameters of the five Sum of Exponential (SOE) functions. Goodness of fit criteria, i.e graph visualization, coefficient of variation (CV<50%), and Correlation Matrix (-0.8 ≤ CMi,j ≥ 0.8), and Akaike Information Criterion (AICc) were used to select the best function then the function was integrated to determine the TIACs value. Five translation methods, i.e. no scaling (NS), mass scaling (MS), time scaling (TS), time-mass scaling (TMS), and allometric scaling (AS) were used to translate the TIACs in mice to human for liver and kidneys. The relative deviations (RDs) of the predicted TIACs in humans from each translation method to the best translation method suggested in Beykan et al study, i.e. TS, were analyzed. The effects of the radiopharmaceutical drugs, i.e. Tras and JR11, to the performance of each translation method i were calculated as Δi=(RDiTras-RDiJR11). As a result, the Δ are 12%(NS); 2%(MS); 2,9%(TMS); and 3,3%(AS) for kidneys and 45,2%(NS); 13,4%(MS); 13,8%(TMS); and 23,5%(AS) for liver. In general, the Δ values are less than 15% except for the NS and AS methods in the liver. It concludes that each method yields totally different prediction from another methods that the best translation method is important for each radiopharmaceutical drugs.
UR - http://www.scopus.com/inward/record.url?scp=85103731532&partnerID=8YFLogxK
U2 - 10.1063/5.0047913
DO - 10.1063/5.0047913
M3 - Conference contribution
AN - SCOPUS:85103731532
T3 - AIP Conference Proceedings
BT - Proceedings of the International Conference and School on Physics in Medicine and Biosystem, ICSPMB 2020
A2 - Lubis, Lukmanda Evan
A2 - Nuzulia, Nur Aisyah
A2 - Hidayati, Nur Rahmah
PB - American Institute of Physics Inc.
T2 - 2020 International Conference and School on Physics in Medicine and Biosystem: Physics Contribution in Medicine and Biomedical Applications, ICSPMB 2020
Y2 - 6 November 2020 through 8 November 2020
ER -