Effect of different radiopharmaceutical drug to the performance of translation methods of TIACs from mice to human

M. Z. Anwari, T. S. Humani, N. R. Hidayati, D. Hardiansyah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

The aim of this study was to investigate the effect of different radiopharmaceutical drugs on the performance of translation method of time-integrated activity coefficient (TIAC) from mice to humans. 177Lu-DOTA-Trastuzumab (Tras) percentage of injected dose (%ID) in Swiss Webster mice at 1, 2, 3, 4, 24, and 48 hours p.i was used to fit the parameters of the five Sum of Exponential (SOE) functions. Goodness of fit criteria, i.e graph visualization, coefficient of variation (CV<50%), and Correlation Matrix (-0.8 ≤ CMi,j ≥ 0.8), and Akaike Information Criterion (AICc) were used to select the best function then the function was integrated to determine the TIACs value. Five translation methods, i.e. no scaling (NS), mass scaling (MS), time scaling (TS), time-mass scaling (TMS), and allometric scaling (AS) were used to translate the TIACs in mice to human for liver and kidneys. The relative deviations (RDs) of the predicted TIACs in humans from each translation method to the best translation method suggested in Beykan et al study, i.e. TS, were analyzed. The effects of the radiopharmaceutical drugs, i.e. Tras and JR11, to the performance of each translation method i were calculated as Δi=(RDiTras-RDiJR11). As a result, the Δ are 12%(NS); 2%(MS); 2,9%(TMS); and 3,3%(AS) for kidneys and 45,2%(NS); 13,4%(MS); 13,8%(TMS); and 23,5%(AS) for liver. In general, the Δ values are less than 15% except for the NS and AS methods in the liver. It concludes that each method yields totally different prediction from another methods that the best translation method is important for each radiopharmaceutical drugs.

Original languageEnglish
Title of host publicationProceedings of the International Conference and School on Physics in Medicine and Biosystem, ICSPMB 2020
Subtitle of host publicationPhysics Contribution in Medicine and Biomedical Applications
EditorsLukmanda Evan Lubis, Nur Aisyah Nuzulia, Nur Rahmah Hidayati
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440876
DOIs
Publication statusPublished - 29 Mar 2021
Event2020 International Conference and School on Physics in Medicine and Biosystem: Physics Contribution in Medicine and Biomedical Applications, ICSPMB 2020 - Depok, Virtual, Indonesia
Duration: 6 Nov 20208 Nov 2020

Publication series

NameAIP Conference Proceedings
Volume2346
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference2020 International Conference and School on Physics in Medicine and Biosystem: Physics Contribution in Medicine and Biomedical Applications, ICSPMB 2020
Country/TerritoryIndonesia
CityDepok, Virtual
Period6/11/208/11/20

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