Effect of dayak onion (Eleutherine bulbosa (mill.) urb) on uterine wall and lipid profiles of ovariectomized rat

Menopause is a physiologic condition, in which women no longer experience menstruation. Decreased estrogen during and after menopause causes structural, physiological and biochemical changes that alter the health of women in general, both in organs and non-reproductive organs. Dayak onion contains eleuterinol, an naphtoqunone derivative that can be as SERM. Therefore, we evaluated the effects of dayak onions on lipid profiles and uterine wall. This study used female white rats of Sprague-Dawley. All groups, except the sham group, is ovariectomized to obtain the conditions of hypoestrogen. Rats were divided into 6 groups. SHAM (CMC Na 0,5%), OVX (CMC Na 0,5%), TAM (tamoxifen), DOE dose 1 (dayak onion extract 8 mg/200), DOE dose 2 (dayak onion extract 12 mg/200 g) and DOE dose 3 (dayak onion extract 18 mg/200 g). Mouse model of ovariectomy given 3 doses of extract, from giving each extract it was seen that the weight of uterine DOE dose 1, DOE dose 2 and DOE dose 3 respectively 55,24, 53,38 and 61,85 mg had lower uterine weight when compared with Positive control given tamoxifen 72.2 mg. The effects of onion on uterine weight reduction are greater than that of tamoxifen on the animal model menopause.