TY - JOUR
T1 - Effect of continuous environmental enrichment and aerobic exercise on rat plasma and hippocampal brain-derived neurotrophic factor
AU - Prasetyo, Sri
AU - Yolanda, Sophie
AU - Ivanali, Kesit
N1 - Funding Information:
The 3rdInternational Conference and Exhibition on Indonesian Medical Education and Research Institute (ICE on IMERI) committee supported the peer review and manuscript preparation of this article. This study was financed by Hibah Publikasi Terindeks Internasional Untuk Tugas Akhir Mahasiswa UI (PITTA), Universitas Indonesia, 2018, no. 2132/UN2.R3.1/HKP. 05.00/2018.
Publisher Copyright:
© 2020 Journal of Natural Science, Biology and Medicine Published by Wolters Kluwer - Medknow.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: Environmental enrichment (EE) or exercise can positively affect memory function through increased long-term potentiation and neurogenesis, which is facilitated by brain-derived neurotrophic factor (BDNF). BDNF promotes blood vessel growth, angiogenesis linked to adult neurogenesis, and neuronal survival. Here, we investigated the effects of EE, aerobic exercise, and their combination on plasma and hippocampal BDNF levels. Materials and Methods: Twenty-four 7-month-old adult male Wistar rats weighing 300-400 g were randomly assigned to the following four groups: control (C), aerobic exercise (A), EE, and combined EE and aerobic exercise (EEA). Interventions were given for 8 weeks, and plasma and hippocampal BDNF levels were measured using enzyme-linked immunosorbent assay. Results: A combination of aerobic exercise and continuous EE produced the largest increase in hippocampal and plasma BDNF levels in adult rats. A positive correlation (r = 0.686, P = 0.002, n = 24) was observed between plasma and hippocampal BDNF levels in adult rats. Conclusion: We conclude that a combination of aerobic exercise and continuous EE increases plasma and hippocampal BDNF in adult rats.
AB - Objective: Environmental enrichment (EE) or exercise can positively affect memory function through increased long-term potentiation and neurogenesis, which is facilitated by brain-derived neurotrophic factor (BDNF). BDNF promotes blood vessel growth, angiogenesis linked to adult neurogenesis, and neuronal survival. Here, we investigated the effects of EE, aerobic exercise, and their combination on plasma and hippocampal BDNF levels. Materials and Methods: Twenty-four 7-month-old adult male Wistar rats weighing 300-400 g were randomly assigned to the following four groups: control (C), aerobic exercise (A), EE, and combined EE and aerobic exercise (EEA). Interventions were given for 8 weeks, and plasma and hippocampal BDNF levels were measured using enzyme-linked immunosorbent assay. Results: A combination of aerobic exercise and continuous EE produced the largest increase in hippocampal and plasma BDNF levels in adult rats. A positive correlation (r = 0.686, P = 0.002, n = 24) was observed between plasma and hippocampal BDNF levels in adult rats. Conclusion: We conclude that a combination of aerobic exercise and continuous EE increases plasma and hippocampal BDNF in adult rats.
KW - Aerobic exercise
KW - brain-derived neurotrophic factor
KW - environmental enrichment
KW - hippocampus
UR - http://www.scopus.com/inward/record.url?scp=85078153563&partnerID=8YFLogxK
U2 - 10.4103/jnsbm.JNSBM_20_19
DO - 10.4103/jnsbm.JNSBM_20_19
M3 - Article
AN - SCOPUS:85078153563
VL - 10
SP - S20-S23
JO - Journal of Natural Science, Biology and Medicine
JF - Journal of Natural Science, Biology and Medicine
SN - 0976-9668
IS - 3
ER -