@inproceedings{a129fb23b0dc452fb8863b2c79709525,
title = "Effect of chitosan molecular weight and composition on mucoadhesive properties of mangostin-loaded chitosan-alginate microparticles",
abstract = "The mucoadhesive properties of chitosan is suitable for extending the residence time of chitosan microparticles in the small intestine and colon. Microparticles prepared using the lowest molecular weight chitosan (62 kDa) showed the highest mucin adsorption of 55-84% and the highest zeta potential of +35.1 mV. Alginate-modified chitosan microparticles (chitosan to alginate mass ratio of 1:0.25) also showed good mucoadhesive properties with 51-79% mucin adsorption and zeta potential of +31.1 mV. The results show that the negatively charged alginate would disrupt the electrostatic interaction between the positively charged chitosan with the negatively charged mucin, and, a higher molecular weight chitosan with lower degree of deacetylation, will have a weaker interaction with mucin.",
keywords = "alginate, chitosan, controlled release, drug delivery, mangostin, microparticles, mucin, mucoadhesive",
author = "Krisanti, {Elsa Anisa} and Aryani, {Sri Dwi} and Kamarza Mulia",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; 1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016 ; Conference date: 31-05-2016 Through 01-06-2016",
year = "2017",
month = feb,
day = "21",
doi = "10.1063/1.4976766",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Yudan Whulanza and Sugeng Supriadi and Muhamad Sahlan and Basari",
booktitle = "Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices",
address = "United States",
}