Effect of cardiopulmonary bypass on lactate metabolism

Iqbal Mustafa, Hubert Roth, Asikin Hanafiah, Tarmizi Hakim, Maizul Anwar, Erwin Siregar, Xavier M. Leverve

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Objective: We have investigated the role of cardiopulmonary bypass on lactate metabolism in patients undergoing uncomplicated surgery for elective coronary artery bypass grafting (CABG). Design: Prospective non-randomized observational study. Settings: National Cardiovascular Center. Patients: Three independent groups were studied: preoperative (n=20), postoperative with bypass (CPB, n=20) and post-operative without bypass (NO-CPB, n=20). Interventions: Lactate metabolism was investigated with the use of an exogenous lactate challenge test (2.5 mmol Na-lactate/kg body weight in 15 min). Blood lactate was sequentially determined after the end of infusion. Lactate clearance and endogenous production were estimated from the area under the curve, and a bi-exponential fitting permitted modeling the lactate-decay into two compartments. Measurements and main results: Lactate metabolism parameters (basal lactate, clearance, endogenous production and half-lives [HL] I and II) were not different between the NO-CPB and preoperative groups. In the CPB group, as compared to the other two groups, basal lactate and endogenous production were not significantly affected while lactate clearance (CPB: 6.02±0.97 versus preoperative: 9.41±0.93 and NO-CPB: 9.6±0.8 ml/kg per min) and HL-I (CPB: 10.6±1.4 versus preoperative: 17.2±2.3 and NO-CPB: 18.8±2.5 min) were decreased (p<0.001) and HL-II was increased (CPB: 171±41 versus preoperative: 73±12 and NO-CPB: 48±2.9 min, p<0.01). Conclusion: While surgery and anesthesia per se do not seem to alter lactate metabolism, CPB significantly decreased lactate clearance, this effect being possibly related to a mild liver dysfunction even in uncomplicated elective surgery.

Original languageEnglish
Pages (from-to)1279-1285
Number of pages7
JournalIntensive Care Medicine
Issue number8
Publication statusPublished - 1 Aug 2003


  • Beating heart surgery
  • Lactate clearance
  • Lactate endogenous production
  • Liver function
  • Modeling


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