@inproceedings{a2240f0d3fd2481ea916fbe290f6ea5a,
title = "Effect of carboxymethyl chitosan on poly(lactic-co-glycolic acid) nanoparticles encapsulating diclofenac sodium: Characterization and in vitro release study",
abstract = "Poly(lactic-co-glycolic acid) is a biocompatible, biodegradable synthetic polymer, has tunable mechanical and degradation rate properties and the capability for controlled drug release. Encapsulation diclofenac sodium using carboxymethyl chitosan-modified poly(lactic-co-glycolic acid) nanoparticles (CMCh/PLGA/DS) were synthesized to enhance gastric retention followed by a controlled release in the small intestine to reduce the side effects due to frequent administration, such as gastric irritation and renal damage. Synthesis of nanoparticles was carried out using a double emulsion (water/oil/water) solvent evaporation method with poly(vinyl alcohol) as the emulsifier. Studies using infrared spectrophotometer show that the interaction between diclofenac sodium and polymer on nanoparticles is non-covalent with a spherical shape based on scanning electron microscope characterization. When compared to unmodified PLGA nanoparticles (PLGA/DS), encapsulation efficiency of CMCh/PLGA/DS nanoparticles was increased with a minimum release at pH 1.2 of 0.2% and controlled release at pH 6.8 of 90.9% up to 24 hours.",
keywords = "carboxymethyl chitosan, controlled release, Diclofenac sodium, PLGA",
author = "D. Lestari and Nizardo, {N. M.} and K. Mulia",
note = "Publisher Copyright: {\textcopyright} 2024 Author(s).; 17th International Conference on Quality in Research, QiR 2021 in conjunction with the International Tropical Renewable Energy Conference 2021, I-Trec 2021 and the 2nd AUN-SCUD International Conference, CAIC-SIUD ; Conference date: 13-10-2021 Through 15-10-2021",
year = "2024",
month = feb,
day = "6",
doi = "10.1063/5.0144382",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
number = "1",
editor = "Andyka Kusuma and Fatriansyah, {Jaka Fajar} and Radon Dhelika and Pratama, {Mochamad Adhiraga} and Ridho Irwansyah and Maknun, {Imam Jauhari} and Putra, {Wahyuaji Narottama} and Romadhani Ardi and Ruki Harwahyu and Harahap, {Yulia Nurliani} and Kenny Lischer",
booktitle = "AIP Conference Proceedings",
address = "United States",
edition = "1",
}