Effect of carboxymethyl chitosan on poly(lactic-co-glycolic acid) nanoparticles encapsulating diclofenac sodium: Characterization and in vitro release study

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Poly(lactic-co-glycolic acid) is a biocompatible, biodegradable synthetic polymer, has tunable mechanical and degradation rate properties and the capability for controlled drug release. Encapsulation diclofenac sodium using carboxymethyl chitosan-modified poly(lactic-co-glycolic acid) nanoparticles (CMCh/PLGA/DS) were synthesized to enhance gastric retention followed by a controlled release in the small intestine to reduce the side effects due to frequent administration, such as gastric irritation and renal damage. Synthesis of nanoparticles was carried out using a double emulsion (water/oil/water) solvent evaporation method with poly(vinyl alcohol) as the emulsifier. Studies using infrared spectrophotometer show that the interaction between diclofenac sodium and polymer on nanoparticles is non-covalent with a spherical shape based on scanning electron microscope characterization. When compared to unmodified PLGA nanoparticles (PLGA/DS), encapsulation efficiency of CMCh/PLGA/DS nanoparticles was increased with a minimum release at pH 1.2 of 0.2% and controlled release at pH 6.8 of 90.9% up to 24 hours.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
EditorsAndyka Kusuma, Jaka Fajar Fatriansyah, Radon Dhelika, Mochamad Adhiraga Pratama, Ridho Irwansyah, Imam Jauhari Maknun, Wahyuaji Narottama Putra, Romadhani Ardi, Ruki Harwahyu, Yulia Nurliani Harahap, Kenny Lischer
PublisherAmerican Institute of Physics Inc.
Edition1
ISBN (Electronic)9780735446410
DOIs
Publication statusPublished - 6 Feb 2024
Event17th International Conference on Quality in Research, QiR 2021 in conjunction with the International Tropical Renewable Energy Conference 2021, I-Trec 2021 and the 2nd AUN-SCUD International Conference, CAIC-SIUD - Virtual, Online, India
Duration: 13 Oct 202115 Oct 2021

Publication series

NameAIP Conference Proceedings
Number1
Volume2710
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference17th International Conference on Quality in Research, QiR 2021 in conjunction with the International Tropical Renewable Energy Conference 2021, I-Trec 2021 and the 2nd AUN-SCUD International Conference, CAIC-SIUD
Country/TerritoryIndia
CityVirtual, Online
Period13/10/2115/10/21

Keywords

  • carboxymethyl chitosan
  • controlled release
  • Diclofenac sodium
  • PLGA

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