Indonesia has a population of 268 million people and 1.1% of the total population does not have access to electricity in 2019, concentrated mostly in the eastern provinces of Indonesia. This is largely due to high cost of setting up electricity grid. Open flume turbine is a pico-hydro water turbine that can generate electricity up to 5 kW with low head, which is suitable for rivers in rural areas in Indonesia. This study compares the performance of pico-hydro open flume turbines designed using different camber line. The turbines are designed to perform at the same head, discharge, and rotation speed. The turbines velocity triangles are identical. The first camber line is drawn using control vertex, the second using interpolation, and the third one is symmetrical camber line. The study is performed using ANSYS Fluent 18.1 and the simulation was performed on 3D, steady-state flow. Based on the result, the turbines yield the highest power at 300 rpm, with the second camber line yield the highest power output of 369.65 Watt, followed by the first camber line with 327.33 Watt, followed by the third camber line with 287.01 Watt.