Effect of calorie restriction diet on levels of C reactive protein (CRP) in obesity: A systematic review and meta-analysis of randomized controlled trials

Indira Kemalasari, Nissha A. Fitri, Robert Sinto, Dicky L. Tahapary, Dante Saksono Harbuwono

Research output: Contribution to journalReview articlepeer-review

Abstract

Background and aims: Chronic inflammation in obese patients can be managed through a calorie-restricted diet, characterized by reduced C - reactive protein (CRP). This study aims to assess the role of such diet on CRP. Methods: Literature searches were performed using search engines. Randomized controlled trials were included. Calorie-restricted diets in combination with non-diet interventions were excluded. Results: Calorie restriction decreased CRP in obese patients with a mean difference of −0.22 (95% CI -0.40 to −0.04, p 0.006). Conclusions: Calorie-restricted diet reduces CRP. Diet administration >12 weeks had a beneficial effect.

Original languageEnglish
Article number102388
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2022

Keywords

  • CRP
  • Obesity
  • Restricted calorie diet

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