Effect of body mass index towards duration of controlled ovarian hyperstimulation in patients undergoing in vitro fertilization

Background: Effect of obesity on response to controlled ovarian hyperstimulation (COH) in assisted reproductive technologies has yielded conflicting results in numerous studies. Obesity may be associated with longer durations and increased amounts of gonadotropin stimulation. Objective: To assess the effect of body mass index (BMI) towards duration of COH in patients undergoing in vitro fertilization (IVF). Methods: Cross-sectional study with data obtained retrospectively among patients undergoing IVF procedure in Yasmin IVF Clinic, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia during 2016. BMI and duration of COH was obtained from medical record. Statistical analysis including comparison and correlation were assessed to reveal significances. Results: Two hundred and eighteen subjects were included in the study with mean of age, BMI, and duration of COH were 35.57 (±4.82) years old, 23.89 (±3.83) kg/m² , and 11.43 (±2.33) days, respectively. Obese patient were found in 72 subjects (33%). There was no significant difference in duration of COH between obese and non-obese subjects (p = 0.495). Moreover, correlation between BMI and duration of ovarian stimulation revealed no significant association (p = 0.129). Conclusions: There was no significant difference in duration of COH between obese and non-obese subjects. BMI was not associated with duration of COH in patients underwent IVF.