Effect of blood estrogen and progesterone on severity of minor RAS

S. Utami, T. W.B. Rahardjo, A. Baziad, T. T. Alwadris, E. I. Auerkari

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


Recurrent Aphthous Stomatitis (RAS) is a chronic inflammatory disease that attacks oral mucosa. Estrogen stimulates proliferation and buccal mucosa cornification and generally acts as an immunoinhibitor that can increase antibody synthesis through humoral response, while progesterone has immunosuppressive potential. This study aimed to examine the levels of blood estrogen and progesterone in females with Minor RAS of varying severity. Subjects were 42 women, 17-40 years old, with Minor RAS but without hormonal therapy or hysterectomy. They were investigated to see whether the severity of pain was related to condition of onset, recurrence and site or amount of lesions. Blood was taken on the 21st - 22nd day of the menstrual cycle to test both hormone levels, using Microparticle Enzyme Immunoassay for the estrogen level, and Competitive Radioimmunoassay for the progesterone level. There was no significant relation between estrogen (p=0.530) or progesterone (p=0.717) level and the severity of Minor RAS. There is a tendency of normal estrogen level on both mild (62.5%) and severe (37.5%) Minor RAS. However, the progesterone level tends to be low both in mild (61.3%) and severe (38.7%) Minor RAS. It is assumed that the decrease of progesterone level also decreases the anti-inflammation function.

Original languageEnglish
Article number012080
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 30 May 2018
Event7th International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application, ISNPINSA 2017 - Semarang, Indonesia
Duration: 17 Oct 201717 Oct 2017


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