TY - JOUR
T1 - Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3
T2 - a cluster-randomized-controlled trial in Indonesia
AU - Kurniawan, Farid
AU - Tahapary, Dicky L.
AU - de Ruiter, Karin
AU - Yunir, Em
AU - Biermasz, Nienke R.
AU - Smit, Johannes W.A.
AU - Supali, Taniawati
AU - Sartono, Erliyani
AU - Yazdanbakhsh, Maria
AU - Soewondo, Pradana
N1 - Funding Information:
The SUGARSPIN study was supported by The Royal Netherlands Academy of Arts and Science (Koninklijke Nederlandse Akademie van Wetenschappen/KNAW), Ref 57-SPIN3-JRP. Data generation was supported by Erasmus+International Mobility Program and The Indonesian Ministry of Research, Technology and Higher Education (World Class Research Grant), Ref. NKB-1087/UN2.R3.1/HKP.05.00/2019. The doctoral study of FK was funded by the scholarship from The Indonesian Endowment Fund for Education (Lembaga Pengelola Dana Pendidikan/LPDP) Ministry of Finance The Republic of Indonesia, Ref S-364/LPDP.3/2019. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; − 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population. Clinical Trial Registration: https://www.isrctn.com/ISRCTN75636394.
AB - In children, soil-transmitted helminth infections have been linked to poor nutritional status and growth retardation in association with lower levels of IGF-1. In adults, IGF-1 has an anabolic and metabolic function and is related to nutritional status. Here, we assessed the impact of helminth infection on free IGF-1 and its major binding protein, IGFBP-3, in adults. The levels of IGF-1 and IGFBP3 were measured in 1669 subjects aged ≥ 16 years, before and after receiving four rounds of albendazole 400 mg/day or matching placebo for three consecutive days. Helminth infection status was assessed by microscopy (Kato-Katz) and PCR. Serum free IGF-1 level was significantly lower in helminth-infected subjects [mean difference and 95% CI − 0.068 (− 0.103; − 0.033), P < 0.001 after adjustment for age, sex, body mass index, and fasting insulin level]. There was no difference in IGFBP-3 level between helminth infected versus non-infected subjects. In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; − 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population. Clinical Trial Registration: https://www.isrctn.com/ISRCTN75636394.
UR - http://www.scopus.com/inward/record.url?scp=85094977317&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-75781-4
DO - 10.1038/s41598-020-75781-4
M3 - Article
AN - SCOPUS:85094977317
SN - 2045-2322
VL - 10
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 19023
ER -