TY - JOUR
T1 - Effect of anthelmintic treatment on leptin, adiponectin and leptin to adiponectin ratio
T2 - a randomized-controlled trial
AU - Tahapary, Dicky Levenus
AU - de Ruiter, K.
AU - Martin, I.
AU - Brienen, E. A.T.
AU - van Lieshout, L.
AU - Djuardi, Yenny
AU - Djimandjaja, C. C.
AU - Houwing-Duistermaat, J. J.
AU - Soewondo, Pradana
AU - Sartono, E.
AU - Supali, Taniawati
AU - Smit, J. W.A.
AU - Yazdanbakhsh, M.
N1 - Funding Information:
We thank Itziar Munos Pagazaurtundua for measuring the adipokines. The Royal Netherlands Academy of Arts and Science (KNAW, Ref 57-SPIN3-JRP), Universitas Indonesia (BOPTN 2742/H2.R12/HKP.05.00/2013).
Publisher Copyright:
© The Author(s) 2017.
PY - 2017
Y1 - 2017
N2 - Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1.20 (1.06–1.35), P = 0.010), which largely stemmed from a significant reduction in adiponectin (0.91 (0.85–0.98), P = 0.020) and a trend for an increase in leptin level (1.10 (1.00–1.21), P = 0.119). No significant effect on resistin level was observed. This increase in leptin to adiponectin ratio seemed to contribute to the observed effect of deworming on increased insulin resistance (IR) as adjustment for leptin to adiponectin ratio attenuated the effect on IR from 1.07 (1.01–1.14, P = 0.023) to 1.05 (0.99–1.11, P = 0.075). Anthelmintic treatment in STH-infected subjects increases leptin to adiponectin ratio which may in small part contribute to the modest increase in IR. Further studies will be needed to assess the effect of the changes in adipokine levels on the host immune response and metabolism.
AB - Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1.20 (1.06–1.35), P = 0.010), which largely stemmed from a significant reduction in adiponectin (0.91 (0.85–0.98), P = 0.020) and a trend for an increase in leptin level (1.10 (1.00–1.21), P = 0.119). No significant effect on resistin level was observed. This increase in leptin to adiponectin ratio seemed to contribute to the observed effect of deworming on increased insulin resistance (IR) as adjustment for leptin to adiponectin ratio attenuated the effect on IR from 1.07 (1.01–1.14, P = 0.023) to 1.05 (0.99–1.11, P = 0.075). Anthelmintic treatment in STH-infected subjects increases leptin to adiponectin ratio which may in small part contribute to the modest increase in IR. Further studies will be needed to assess the effect of the changes in adipokine levels on the host immune response and metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85047945117&partnerID=8YFLogxK
U2 - 10.1038/NUTD.2017.37
DO - 10.1038/NUTD.2017.37
M3 - Article
C2 - 29035384
AN - SCOPUS:85047945117
SN - 2044-4052
VL - 7
JO - Nutrition and Diabetes
JF - Nutrition and Diabetes
IS - 10
M1 - e289
ER -