Effect of age on human peripheral blood stem cells

Yoshihiro Egusa, Yasuhiro Fujiwara, Elisna Syahruddin, Takeshi Isobe, Michio Yamakido

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

We evaluated the correlation between the number of peripheral blood stem cells (PBSCs) and aging by monitoring those of CD34 + cells (PB-CD34 + ), colony-forming unit granulocyte macrophages (PB-CFU-GM) per 1 ml of peripheral blood in normal volunteers (n=50) including 20 males and 30 females (median age 67, range 20-90). The numbers of PB-CD34 + , PB-CFU-GM were monitored by flow cytometry and methylcellulose-based colony assay, respectively. An inverse correlation between the number of PB-CD34 + with age (r=-0.33, p=0.020) was found. Furthermore, the number of PB-CFU-GM also showed an inverse correlation with age (r=-0.58, p=0.003). Based on these results, it is suggested that the number of PBSCs decrease with age.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalOncology Reports
Volume5
Issue number2
Publication statusPublished - 18 Mar 1998

Keywords

  • Aging
  • CD34
  • CFU-GM
  • Peripheral blood stem cells

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