Effect of 70% ethanol extract of Orthosiphonis stamineus benth leaves on the pharmacokinetic parameters of furosemide in male white rats

Riana Maya Oktaviani, Santi Purna Sari, Yahdiana Harahap

Research output: Contribution to journalArticle

Abstract

Objective: This study aimed to observe the effect of the 70% ethanol extract of Orthosiphonis stamineus Benth leaves on the pharmacokinetic parameters of furosemide in white male rats. Methods: 18 Sprague–Dawley male rats were divided into three groups: The normal control group was given only 1% carboxymethyl cellulose, the furosemide group was given 7.2 mg/200 g body weight (BW) suspension of furosemide, and the combination group was given 700 mg/kg BW suspension of the 70% ethanolic extract of O. stamineus Benth leaves for 4 days followed by a 7.2 mg/200 g BW suspension of furosemide. On the 4th day of treatment, we performed orbital sinus blood sampling on the eyes of the rats and analyzed the levels of furosemide in plasma using high-performance liquid chromatography. Results: Therefore, the results showed that the administration of the 70% ethanol extract of O. stamineus Benth leaves improves the pharmacokinetic parameters of furosemide on Cpmax and the area under the curve (p<0.05). Conclusion: This study concludes that the 70% ethanol extract of O. stamineus Benth leaves improves the pharmacokinetic parameters of furosemide in white male rats.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalInternational Journal of Applied Pharmaceutics
Volume9
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • 70% ethanolic extract
  • Cat’s whiskers leaves
  • Furosemide
  • Orthosiphonis stamineus Benth
  • Pharmacokinetic

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