Effect drug loading process on dissolution mechanism of encapsulated amoxicillin trihydrate in hydrogel semi -IPN chitosan methyl cellulose with pore forming agent KHCO3 as a floating drug delivery system

Garnis Fithawati, Emil Budianto

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Common treatment for Helicobacter pylori by repeated oral consumption of amoxicillin trihydrate is not effective. Amoxicillin trihydrate has a very short residence time in stomach which leads into its ineffectiveness. Residence time of amoxicillin trihydrate can be improved by encapsulating amoxicillin trihydrate into a floating drug delivery system. In this study, amoxicillin trihydrate is encapsulated into hydrogel semi-IPN chitosan methyl cellulose matrix as a floating drug delivery system and then treated with 20% KHCO3 as pore forming agent. Drug loading process used are in-situ loading and post loading. In-situ loading process has higher efficiency percentage and dissolution percentage than post loading process. In-situ loading process resulted 100% efficiency with 92,70% dissolution percentage. Post loading process resulted 98,7% efficiency with 90,42% dissolution percentage. Mechanism of drug dissolution study by kinetics approach showed both in-situ loading process and post loading process are diffusion and degradation process (n=0,4913) and (n=0,4602) respectively. These results are supported by characterization data from optical microscope and scanning electron microscopy (SEM). Data from optical microscope showed both loading process resulted in coarser hydrogel surface. Characterization using SEM showed elongated pores in both loading process after dissolution test.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
Subtitle of host publicationAdvancing Innovation in Materials Science, Technology and Applications for Sustainable Future
EditorsMas Irfan P. Hidayat
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735416406
DOIs
Publication statusPublished - 3 Apr 2018
Event3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 - Surabaya, Indonesia
Duration: 30 Oct 201731 Oct 2017

Publication series

NameAIP Conference Proceedings
Volume1945
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
CountryIndonesia
CitySurabaya
Period30/10/1731/10/17

Keywords

  • Floating drug delivery system
  • in-situ loading
  • mechanism dissolution
  • pore forming agent 20% KHCO
  • post loading

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