TY - GEN
T1 - Effect drug loading process on dissolution mechanism of encapsulated amoxicillin trihydrate in hydrogel semi -IPN chitosan methyl cellulose with pore forming agent KHCO3 as a floating drug delivery system
AU - Fithawati, Garnis
AU - Budianto, Emil
N1 - Funding Information:
The Authors would like to thank Directorate of Research and Community Engagement (DRPM) Universitas Indonesia for supporting our research financially through Hibah Publikasi Internasional Terindeks untuk Tugas Akhir (Hibah PITTA) 2017. I am also would like to thank Department of Chemistry and Institute for Advancement of Science Technology and Humanity (IASTH), Universitas Indonesia for supporting us and providing the instrumental facilities for our research. Emil Budianto as the supervisor in this research and designed the research pipeline, while Garnis Fithawati conducted the experimental details, analyzed the data and wrote the final manuscript. Herewith, we would declare that there is no conflict of interest regarding this manuscript.
Publisher Copyright:
© 2018 Author(s).
PY - 2018/4/3
Y1 - 2018/4/3
N2 - Common treatment for Helicobacter pylori by repeated oral consumption of amoxicillin trihydrate is not effective. Amoxicillin trihydrate has a very short residence time in stomach which leads into its ineffectiveness. Residence time of amoxicillin trihydrate can be improved by encapsulating amoxicillin trihydrate into a floating drug delivery system. In this study, amoxicillin trihydrate is encapsulated into hydrogel semi-IPN chitosan methyl cellulose matrix as a floating drug delivery system and then treated with 20% KHCO3 as pore forming agent. Drug loading process used are in-situ loading and post loading. In-situ loading process has higher efficiency percentage and dissolution percentage than post loading process. In-situ loading process resulted 100% efficiency with 92,70% dissolution percentage. Post loading process resulted 98,7% efficiency with 90,42% dissolution percentage. Mechanism of drug dissolution study by kinetics approach showed both in-situ loading process and post loading process are diffusion and degradation process (n=0,4913) and (n=0,4602) respectively. These results are supported by characterization data from optical microscope and scanning electron microscopy (SEM). Data from optical microscope showed both loading process resulted in coarser hydrogel surface. Characterization using SEM showed elongated pores in both loading process after dissolution test.
AB - Common treatment for Helicobacter pylori by repeated oral consumption of amoxicillin trihydrate is not effective. Amoxicillin trihydrate has a very short residence time in stomach which leads into its ineffectiveness. Residence time of amoxicillin trihydrate can be improved by encapsulating amoxicillin trihydrate into a floating drug delivery system. In this study, amoxicillin trihydrate is encapsulated into hydrogel semi-IPN chitosan methyl cellulose matrix as a floating drug delivery system and then treated with 20% KHCO3 as pore forming agent. Drug loading process used are in-situ loading and post loading. In-situ loading process has higher efficiency percentage and dissolution percentage than post loading process. In-situ loading process resulted 100% efficiency with 92,70% dissolution percentage. Post loading process resulted 98,7% efficiency with 90,42% dissolution percentage. Mechanism of drug dissolution study by kinetics approach showed both in-situ loading process and post loading process are diffusion and degradation process (n=0,4913) and (n=0,4602) respectively. These results are supported by characterization data from optical microscope and scanning electron microscopy (SEM). Data from optical microscope showed both loading process resulted in coarser hydrogel surface. Characterization using SEM showed elongated pores in both loading process after dissolution test.
KW - Floating drug delivery system
KW - in-situ loading
KW - mechanism dissolution
KW - pore forming agent 20% KHCO
KW - post loading
UR - http://www.scopus.com/inward/record.url?scp=85045676714&partnerID=8YFLogxK
U2 - 10.1063/1.5030236
DO - 10.1063/1.5030236
M3 - Conference contribution
AN - SCOPUS:85045676714
T3 - AIP Conference Proceedings
BT - Proceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
A2 - Hidayat, Mas Irfan P.
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Y2 - 30 October 2017 through 31 October 2017
ER -