Background: Elective craniotomy is associated with a high incidence of postoperative pulmonary complications/PPC (25%) and mortality (10%); in which these incidence went down with the administration of low tidal volume. This study investigated the effect of low tidal volume in intraoperative PaO2/FiO2 ratio in elective craniotomy patients.
Subject and Methods: After approval from Ethics Committee Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital and consent from patients,a randomized controlled trialwas done to 52 elective craniotomy patients. Subjects were ventilated with tidal volume 6 mL/kg (VT–6) or 10 mL/kg (VT–10) intraoperatively, then blood gas analyses wereperformed.
Results: PaO2/FiO2 ratio of VT–6 and VT–10 respectively: at 1 hour postinduction, 413.7 ± 113.4 mmHg and 401.5 ± 106.3 mmHg (p>0.05); at end of surgery, 466.6 ± 94.6 mmHg and 471.1 ± 89.0 mmHg (p>0.05); at 24 hours postinduction, 418.8 ± 108.8 and 448.5± 119.6 mmHg (p>0.05); at 48 hours postinduction, 414.9 ± 88.1 mmHg and 402.5 ± 100.7 mmHg (p>0.05). There were no significant differences on mortality, lung and extralung complications observed between both groups.
Conclusions: There were no significant difference between tidal volume 6 ml/kg and 10 ml/kg against intraoperative PaO2/FiO2 ratio in elective craniotomy patients.