TY - JOUR
T1 - Dysregulation of kisspeptin and leptin, as anorexigenic agents, plays role in the development of obesity in postmenopausal women
AU - Hestiantoro, Andon
AU - Astuti, Brilliant P.K.
AU - Muharam, Raden
AU - Pratama, Gita
AU - Witjaksono, Fiastuti
AU - Wiweko, Budi
N1 - Funding Information:
The authors would like to thank Human Reproductive, Infertility, and Family Planning Cluster Indonesian Medical Education and Research Institute (IMERI) for supporting this research.
Publisher Copyright:
© 2019 Andon Hestiantoro et al.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - During the menopausal period, women have a higher tendency to develop obesity and any other metabolic syndromes. Dysregulation of leptin and kisspeptin signaling as anorexigenic agents is believed to be the connection between metabolic disorders and altered reproductive function. Therefore, this study aimed at investigating the association between leptin, soluble leptin receptor (sOBR), free leptin index, kisspeptin concentrations, and body mass index (BMI) in postmenopausal women. A cross-sectional study was carried out among 171 postmenopausal women aged 40-75 years from 2017 to 2018. Subjects were assigned into 2 groups according to their BMIs: obese group (84 subjects) and nonobese group (87 subjects). In addition to anthropometric measurement, blood sample was collected from each subject for leptin, sOBR, free leptin index (FLI), and kisspeptin evaluation. Bivariate and correlation analysis discovered that leptin and FLI were positively correlated with BMI, while sOBR and kisspeptin were negatively correlated with BMI. Among those variables, multivariate analysis found that leptin, sOBR, and kisspeptin were independently associated with obesity. Therefore, it can be concluded that higher serum leptin concentration and FLI, as well as lower serum sOBR and kisspeptin concentrations, are significantly associated with obesity in postmenopausal women.
AB - During the menopausal period, women have a higher tendency to develop obesity and any other metabolic syndromes. Dysregulation of leptin and kisspeptin signaling as anorexigenic agents is believed to be the connection between metabolic disorders and altered reproductive function. Therefore, this study aimed at investigating the association between leptin, soluble leptin receptor (sOBR), free leptin index, kisspeptin concentrations, and body mass index (BMI) in postmenopausal women. A cross-sectional study was carried out among 171 postmenopausal women aged 40-75 years from 2017 to 2018. Subjects were assigned into 2 groups according to their BMIs: obese group (84 subjects) and nonobese group (87 subjects). In addition to anthropometric measurement, blood sample was collected from each subject for leptin, sOBR, free leptin index (FLI), and kisspeptin evaluation. Bivariate and correlation analysis discovered that leptin and FLI were positively correlated with BMI, while sOBR and kisspeptin were negatively correlated with BMI. Among those variables, multivariate analysis found that leptin, sOBR, and kisspeptin were independently associated with obesity. Therefore, it can be concluded that higher serum leptin concentration and FLI, as well as lower serum sOBR and kisspeptin concentrations, are significantly associated with obesity in postmenopausal women.
UR - http://www.scopus.com/inward/record.url?scp=85076998322&partnerID=8YFLogxK
U2 - 10.1155/2019/1347208
DO - 10.1155/2019/1347208
M3 - Article
AN - SCOPUS:85076998322
SN - 1687-8337
VL - 2019
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 1347208
ER -