Drug Rash Eosinophilia and Systemic Symptoms

Drug Rash Eosinophilia and Systemic Symptoms (DRESS) is a life threatening condition that is characterized with skin rash, fever, leukocytosis with eosinophilia or atypical lymphocytosis, lymphadenopathy, and liver or kidney involvement. Mortality rate in DRESS can reach 10%. Drug Rash Eosinophilia and Systemic Symptomsis is caused by exposure against triggering drugs in suspectible individual. Suspectible individual could be hereditary factors (gender, genetic polymorphism) or acquired factors (systemic lupus erythematosus, lymphoma, viral infection). Management of DRESS are prompt withdrawal of the offending drug, supportive therapy, and systemic corticosteroid administration. Supportive therapy including adecuate nutritional support and intravenous fluid, antihistamine, or antipyretic. Systemic corticosteroid is administered with doses 1-1,5 mg/BW/day equal of prednisone that is tapered down gradually to prevent flare up.