High power consumption in piping system due to high pressure losses in a turbulent flow has been recognized as a critical problem occurring to fluid flows in various industrial piping systems, including crude oil transportation in the oil and gas sector. To solve the problem, a drag reducing agent (DRA) is added into crude oil flow for improving the pumping efficiency. One of most technically effective, low costs and well-known DRA is anionic surfactant. Thus, the purpose of this study is to investigate the pressure drop reduction by adding anionic surfactant sodium lauryl sulphate (SLS) at different concentrations into crude oil flow in a pentagon spiral pipe. Moreover, our study also reveals the drag reduction mechanism by showing its velocity profile by using computational fluid dynamic (CFD) method. Effectiveness of the DRA was comparatively observed in a pentagon spiral pipe with 10.8 ratio of diameter (P/Di) and in a circular pipe with 4 mm inner diameter. Meanwhile, CFD method to reveal its velocity profile was done using ANSYS-Fluent. Then, a certain concentration of anionic surfactant SLS is observed to actively reduce friction factor.