DNA vaccination associated with eliminating inheritance risks during embryo development: A review

Research output: Contribution to journalReview articlepeer-review

Abstract

The process of immunization using modified DNA is essential whenever scientists desire to trigger an artificial response in the host’s body to improve immunity. The use of DNA vaccines awakens the somatic cells of the host to produce antigens that will assist the body to prepare to fight infections through preventive measures triggered by the vaccines. These biological inventions have assisted in controlling diseases as well as eliminating some health conditions. Scientific analyses have shown how the plasmid DNA could trigger an artificial immune response in living organisms when associated with the antigens that are plasmidencoded. Such revelations have demonstrated that this invention has a possible therapeutic application as vaccination to prevent numerous pathogens and their related infections. This paper reviews the concept of DNA vaccination and its effects on embryogenesis. The paper first discusses an overview of DNA vaccines and relates it to the production and expression processes. The effects on embryo development have also been described. This review also explains the advantages and disadvantages related to DNA vaccines’ administration and the mechanisms employed to enhance plasmid effectiveness.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalOnLine Journal of Biological Sciences
Volume16
Issue number2
DOIs
Publication statusPublished - 2016

Keywords

  • Antibodies
  • DNA Vaccination
  • Embryogenesis
  • Major histocompatibility complex (MHC) and antigen presenting cells (APC)
  • Transfection

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