DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry

Angger Waspodo Dias Adrianto; Bambang Tri Hartomo; Nurtami Soedarsono; Elza Ibrahim Auerkari

doi:10.1063/1.5139339

DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry

Angger Waspodo Dias Adrianto
, Bambang Tri Hartomo
, Nurtami Soedarsono
, Elza Ibrahim Auerkari

Department of Oral Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N⁷- methylguanine, O⁶-methylguanine, and O⁴-methylthymine. O⁶-methylguanine or O⁶-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.

Original language	English
Title of host publication	4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publication	Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019
Editors	Kenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419445
DOIs	https://doi.org/10.1063/1.5139339
Publication status	Published - 10 Dec 2019
Event	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia Duration: 22 Jul 2019 → 24 Jul 2019

Publication series

Name	AIP Conference Proceedings
Volume	2193
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/Territory	Indonesia
City	Padang, West Sumatera
Period	22/07/19 → 24/07/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA adduct
Forensic Dentistry
Genotoxicity

Access to Document

10.1063/1.5139339

Cite this

Adrianto, A. W. D., Hartomo, B. T., Soedarsono, N., & Auerkari, E. I. (2019). DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry. In K. Lischer, T. Abuzairi, S. F. Rahman, & M. Gozan (Eds.), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019 Article 030002 (AIP Conference Proceedings; Vol. 2193). American Institute of Physics Inc.. https://doi.org/10.1063/1.5139339

Adrianto, Angger Waspodo Dias ; Hartomo, Bambang Tri ; Soedarsono, Nurtami et al. / DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry. 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. editor / Kenny Lischer ; Tomy Abuzairi ; Siti Fauziyah Rahman ; Misri Gozan. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

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title = "DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry",

abstract = "In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N7- methylguanine, O6-methylguanine, and O4-methylthymine. O6-methylguanine or O6-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.",

keywords = "DNA adduct, Forensic Dentistry, Genotoxicity",

author = "Adrianto, \{Angger Waspodo Dias\} and Hartomo, \{Bambang Tri\} and Nurtami Soedarsono and Auerkari, \{Elza Ibrahim\}",

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year = "2019",

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doi = "10.1063/1.5139339",

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publisher = "American Institute of Physics Inc.",

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Adrianto, AWD, Hartomo, BT, Soedarsono, N & Auerkari, EI 2019, DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry. in K Lischer, T Abuzairi, SF Rahman & M Gozan (eds), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019., 030002, AIP Conference Proceedings, vol. 2193, American Institute of Physics Inc., 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019, Padang, West Sumatera, Indonesia, 22/07/19. https://doi.org/10.1063/1.5139339

DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry. / Adrianto, Angger Waspodo Dias; Hartomo, Bambang Tri; Soedarsono, Nurtami et al.
4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. ed. / Kenny Lischer; Tomy Abuzairi; Siti Fauziyah Rahman; Misri Gozan. American Institute of Physics Inc., 2019. 030002 (AIP Conference Proceedings; Vol. 2193).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry

AU - Adrianto, Angger Waspodo Dias

AU - Hartomo, Bambang Tri

AU - Soedarsono, Nurtami

AU - Auerkari, Elza Ibrahim

PY - 2019/12/10

Y1 - 2019/12/10

N2 - In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N7- methylguanine, O6-methylguanine, and O4-methylthymine. O6-methylguanine or O6-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.

AB - In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N7- methylguanine, O6-methylguanine, and O4-methylthymine. O6-methylguanine or O6-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.

KW - DNA adduct

KW - Forensic Dentistry

KW - Genotoxicity

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DO - 10.1063/1.5139339

M3 - Conference contribution

AN - SCOPUS:85076753237

T3 - AIP Conference Proceedings

BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices

A2 - Lischer, Kenny

A2 - Abuzairi, Tomy

A2 - Rahman, Siti Fauziyah

A2 - Gozan, Misri

PB - American Institute of Physics Inc.

T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019

Y2 - 22 July 2019 through 24 July 2019

ER -

Adrianto AWD, Hartomo BT, Soedarsono N , Auerkari EI. DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry. In Lischer K, Abuzairi T, Rahman SF, Gozan M, editors, 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. American Institute of Physics Inc. 2019. 030002. (AIP Conference Proceedings). doi: 10.1063/1.5139339

DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry

Abstract

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UN SDGs

Keywords

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