TY - GEN
T1 - DNA adducts, genotoxicity mechanism of alkyl compounds in association with forensic dentistry
AU - Adrianto, Angger Waspodo Dias
AU - Hartomo, Bambang Tri
AU - Soedarsono, Nurtami
AU - Auerkari, Elza Ibrahim
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/12/10
Y1 - 2019/12/10
N2 - In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N7- methylguanine, O6-methylguanine, and O4-methylthymine. O6-methylguanine or O6-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.
AB - In addition to fingerprints and DNA analysis, forensic dentistry through dental records offers one of the main methods of forensic identification in challenging cases. Combining the methods of forensic dentistry and DNA analysis can further improve the chances of positive identification. Often the sampling of the victim is done in the area of the mouth, teeth, and periodontal tissue, then DNA testing is carried out. One test type aims to characterize the DNA damage (DNA adducts) induced by alkylating agent genotoxicity. The DNA adducts that can be observed are N7- methylguanine, O6-methylguanine, and O4-methylthymine. O6-methylguanine or O6-methylguanine methyltransferase (MGMT) as repair pathway can be a biomarker of oral squamous cell carcinoma. Therefore, the role of forensic dentistry to analyze oral cancer as one cause of a person's death.
KW - DNA adduct
KW - Forensic Dentistry
KW - Genotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85076753237&partnerID=8YFLogxK
U2 - 10.1063/1.5139339
DO - 10.1063/1.5139339
M3 - Conference contribution
AN - SCOPUS:85076753237
T3 - AIP Conference Proceedings
BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
A2 - Lischer, Kenny
A2 - Abuzairi, Tomy
A2 - Rahman, Siti Fauziyah
A2 - Gozan, Misri
PB - American Institute of Physics Inc.
T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Y2 - 22 July 2019 through 24 July 2019
ER -
