Distribution Pattern of Polymeric Immunoglobulin Receptor (PIGR) Gene Allotype in Nasopharyngeal Carcinoma (NPC) Patients in Indonesia

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Abstract

Nasopharyngeal Carcinoma (NPC) is a multifactor disease with a characteristic of endemicity and a prominent geographical distribution. In addition to the presence of Epstein-Barr virus (EBV) infection, NPC incidence emerges due to the role of genetic factors such as PIGR gene polymorphism. The aim of this study was to study allotype distribution of PIGR gene and its relation with individual susceptibility to NPC in Indonesian population. The study was conducted using PCR-RFLP analysis of PIGR gene using a restriction enzyme Hga I. Determination of allele PIGR gene was conducted on NPC patients and healthy controls from some tribe populations and Indonesian ethnic that exist in Jakarta. The result showed that the difference of genotypic distribution and allele frequency of PIGR gene in NPC patients as compared to healthy control individuals and between indigenous group and Chinese ethnic in Indonesia, both T allele or C allele, were not statistically significant. The study showed the posibility allotype of PIGR gene does not associate to NPC carcinogenesis in Indonesian population. However, further studies which involve large sample representing the many Indonesian subpopulations are required to confirm this finding
Original languageEnglish
JournalJournal of the Indonesian Medical Association
Publication statusPublished - Nov 2010

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