Periodontitis is a complex chronic infection of the periodontal tissues. One of the risk factors of periodontitis is genetic: vitamin D receptor (VDR)-1056 T/C gene polymorphism, which is involved in bone metabolism and affects immune function in a way that leads to bone resorption in periodontitis. In this cross-sectional study, we investigated the difference in the distribution pattern of the VDR-1056 T/C gene polymorphism between patients with periodontitis and a healthy control group. The VDR-1056 T/C gene polymorphism was analyzed by the polymerase chain reaction–restriction (PCR) fragment‑length polymorphism method with Taq I restriction enzyme digestion. We found that among all participants with the TC genotype, the VDR-1056 T/C gene polymorphism was present in 44.55% of participants with periodontitis and in 55.6% of the control group. This finding indicated that among patients with periodontitis, the VDR-1056 T/C gene polymorphism was present in 44.5% of those with the TC genotype, in 50.5% of those with the TT genotype, and in 0% of those with the CC genotype. But there was no significant difference in the distributions of VDR-1056 T/C gene polymorphism between patients with periodontitis and the control group (P=1.0).
|Number of pages
|Journal of International Dental and Medical Research
|Published - 2020
- vitamin D receptor