TY - JOUR
T1 - Distribution of Vitamin D Receptor–1056 T/C Polymorphism in Healthy People and Patients with Periodontitis
AU - Dinda, Isni Rachma
AU - Suhartono, Antonius Winoto
AU - Listyowati, L.
AU - Masulili, Sri Lelyati
AU - Auerkari, Elza Ibrahim
N1 - Funding Information:
The authors gratefully acknowledge the financial support of Ministry of Education and Culture through the Directorate of Research and Public Services of the University of Indonesia 2019 to Elza Ibrahim Auerkari. The publication of this manuscript is supported by Universitas Indonesia.
Publisher Copyright:
© 2020. All Rights Reserved.
PY - 2020
Y1 - 2020
N2 - Periodontitis is a complex chronic infection of the periodontal tissues. One of the risk factors of periodontitis is genetic: vitamin D receptor (VDR)-1056 T/C gene polymorphism, which is involved in bone metabolism and affects immune function in a way that leads to bone resorption in periodontitis. In this cross-sectional study, we investigated the difference in the distribution pattern of the VDR-1056 T/C gene polymorphism between patients with periodontitis and a healthy control group. The VDR-1056 T/C gene polymorphism was analyzed by the polymerase chain reaction–restriction (PCR) fragment‑length polymorphism method with Taq I restriction enzyme digestion. We found that among all participants with the TC genotype, the VDR-1056 T/C gene polymorphism was present in 44.55% of participants with periodontitis and in 55.6% of the control group. This finding indicated that among patients with periodontitis, the VDR-1056 T/C gene polymorphism was present in 44.5% of those with the TC genotype, in 50.5% of those with the TT genotype, and in 0% of those with the CC genotype. But there was no significant difference in the distributions of VDR-1056 T/C gene polymorphism between patients with periodontitis and the control group (P=1.0).
AB - Periodontitis is a complex chronic infection of the periodontal tissues. One of the risk factors of periodontitis is genetic: vitamin D receptor (VDR)-1056 T/C gene polymorphism, which is involved in bone metabolism and affects immune function in a way that leads to bone resorption in periodontitis. In this cross-sectional study, we investigated the difference in the distribution pattern of the VDR-1056 T/C gene polymorphism between patients with periodontitis and a healthy control group. The VDR-1056 T/C gene polymorphism was analyzed by the polymerase chain reaction–restriction (PCR) fragment‑length polymorphism method with Taq I restriction enzyme digestion. We found that among all participants with the TC genotype, the VDR-1056 T/C gene polymorphism was present in 44.55% of participants with periodontitis and in 55.6% of the control group. This finding indicated that among patients with periodontitis, the VDR-1056 T/C gene polymorphism was present in 44.5% of those with the TC genotype, in 50.5% of those with the TT genotype, and in 0% of those with the CC genotype. But there was no significant difference in the distributions of VDR-1056 T/C gene polymorphism between patients with periodontitis and the control group (P=1.0).
KW - Periodontitis
KW - vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=85103498516&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85103498516
SN - 1309-100X
VL - 13
SP - 1510
EP - 1514
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 4
ER -