Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study

Widya Dwi Honesty Putri Soewarlan; Hedijanti Joenoes; Shafa Ahmad Bawazier; Dwi Anita Suryandari; Elza Ibrahim Auerkari

doi:10.1063/1.5096727

Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study

Widya Dwi Honesty Putri Soewarlan, Hedijanti Joenoes, Shafa Ahmad Bawazier, Dwi Anita Suryandari, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Osteoporosis is a condition that is characterized by reduced bone mass and micro-architectural deterioration. Previous studies have shown that the MTHFR C677T polymorphism may be involved in the development of osteoporosis. The aim of this study was to characterise the distribution of this polymorphism in 100 Indonesian postmenopausal women. The MTHFR C677T polymorphism were determined in 25 women with osteopenia, 50 women with osteoporosis, and 25 control subjects using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique with Hinf1 enzyme. The results showed CC genotype (wild type) 70%, CT genotype (heterozygous polymorphic) 29%, and TT genotype (homozygous polymorphic) 1%, with a T-allele frequency of 15.5%. The result also showed that there was no significant variation with MTHFR C677T genotype. It can be concluded that the MTHFR C677T polymorphism was weakly associated with BMD (Bone Mineral Density).

Original language	English
Title of host publication	3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publication	Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018
Editors	Praswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735418226
DOIs	https://doi.org/10.1063/1.5096727
Publication status	Published - 9 Apr 2019
Event	3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia Duration: 6 Aug 2018 → 8 Aug 2018

Publication series

Name	AIP Conference Proceedings
Volume	2092
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Country/Territory	Indonesia
City	Jakarta
Period	6/08/18 → 8/08/18

Keywords

Bone mineral density
MTHFR
osteoporosis
polymorphism

Access to Document

10.1063/1.5096727

Cite this

Soewarlan, W. D. H. P., Joenoes, H., Bawazier, S. A., Suryandari, D. A., & Auerkari, E. I. (2019). Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study. In P. P. D. K. Wulan, M. Gozan, S. Astutiningsih, G. Ramahdita, R. Dhelika, & P. Kreshanti (Eds.), 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018 Article 030023 (AIP Conference Proceedings; Vol. 2092). American Institute of Physics Inc.. https://doi.org/10.1063/1.5096727

Soewarlan, Widya Dwi Honesty Putri ; Joenoes, Hedijanti ; Bawazier, Shafa Ahmad et al. / Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study. 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018. editor / Praswasti P.D.K. Wulan ; Misri Gozan ; Sotya Astutiningsih ; Ghiska Ramahdita ; Radon Dhelika ; Prasetyanugraheni Kreshanti. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

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title = "Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study",

abstract = "Osteoporosis is a condition that is characterized by reduced bone mass and micro-architectural deterioration. Previous studies have shown that the MTHFR C677T polymorphism may be involved in the development of osteoporosis. The aim of this study was to characterise the distribution of this polymorphism in 100 Indonesian postmenopausal women. The MTHFR C677T polymorphism were determined in 25 women with osteopenia, 50 women with osteoporosis, and 25 control subjects using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique with Hinf1 enzyme. The results showed CC genotype (wild type) 70%, CT genotype (heterozygous polymorphic) 29%, and TT genotype (homozygous polymorphic) 1%, with a T-allele frequency of 15.5%. The result also showed that there was no significant variation with MTHFR C677T genotype. It can be concluded that the MTHFR C677T polymorphism was weakly associated with BMD (Bone Mineral Density).",

keywords = "Bone mineral density, MTHFR, osteoporosis, polymorphism",

author = "Soewarlan, {Widya Dwi Honesty Putri} and Hedijanti Joenoes and Bawazier, {Shafa Ahmad} and Suryandari, {Dwi Anita} and Auerkari, {Elza Ibrahim}",

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doi = "10.1063/1.5096727",

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Soewarlan, WDHP, Joenoes, H, Bawazier, SA, Suryandari, DA & Auerkari, EI 2019, Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study. in PPDK Wulan, M Gozan, S Astutiningsih, G Ramahdita, R Dhelika & P Kreshanti (eds), 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018., 030023, AIP Conference Proceedings, vol. 2092, American Institute of Physics Inc., 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018, Jakarta, Indonesia, 6/08/18. https://doi.org/10.1063/1.5096727

Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study. / Soewarlan, Widya Dwi Honesty Putri; Joenoes, Hedijanti; Bawazier, Shafa Ahmad et al.
3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018. ed. / Praswasti P.D.K. Wulan; Misri Gozan; Sotya Astutiningsih; Ghiska Ramahdita; Radon Dhelika; Prasetyanugraheni Kreshanti. American Institute of Physics Inc., 2019. 030023 (AIP Conference Proceedings; Vol. 2092).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study

AU - Soewarlan, Widya Dwi Honesty Putri

AU - Joenoes, Hedijanti

AU - Bawazier, Shafa Ahmad

AU - Suryandari, Dwi Anita

AU - Auerkari, Elza Ibrahim

PY - 2019/4/9

Y1 - 2019/4/9

N2 - Osteoporosis is a condition that is characterized by reduced bone mass and micro-architectural deterioration. Previous studies have shown that the MTHFR C677T polymorphism may be involved in the development of osteoporosis. The aim of this study was to characterise the distribution of this polymorphism in 100 Indonesian postmenopausal women. The MTHFR C677T polymorphism were determined in 25 women with osteopenia, 50 women with osteoporosis, and 25 control subjects using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique with Hinf1 enzyme. The results showed CC genotype (wild type) 70%, CT genotype (heterozygous polymorphic) 29%, and TT genotype (homozygous polymorphic) 1%, with a T-allele frequency of 15.5%. The result also showed that there was no significant variation with MTHFR C677T genotype. It can be concluded that the MTHFR C677T polymorphism was weakly associated with BMD (Bone Mineral Density).

AB - Osteoporosis is a condition that is characterized by reduced bone mass and micro-architectural deterioration. Previous studies have shown that the MTHFR C677T polymorphism may be involved in the development of osteoporosis. The aim of this study was to characterise the distribution of this polymorphism in 100 Indonesian postmenopausal women. The MTHFR C677T polymorphism were determined in 25 women with osteopenia, 50 women with osteoporosis, and 25 control subjects using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique with Hinf1 enzyme. The results showed CC genotype (wild type) 70%, CT genotype (heterozygous polymorphic) 29%, and TT genotype (homozygous polymorphic) 1%, with a T-allele frequency of 15.5%. The result also showed that there was no significant variation with MTHFR C677T genotype. It can be concluded that the MTHFR C677T polymorphism was weakly associated with BMD (Bone Mineral Density).

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KW - MTHFR

KW - osteoporosis

KW - polymorphism

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M3 - Conference contribution

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T3 - AIP Conference Proceedings

BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices

A2 - Wulan, Praswasti P.D.K.

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A2 - Ramahdita, Ghiska

A2 - Dhelika, Radon

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Soewarlan WDHP, Joenoes H, Bawazier SA, Suryandari DA , Auerkari EI. Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study. In Wulan PPDK, Gozan M, Astutiningsih S, Ramahdita G, Dhelika R, Kreshanti P, editors, 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2018. American Institute of Physics Inc. 2019. 030023. (AIP Conference Proceedings). doi: 10.1063/1.5096727

Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study

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