Distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in postmenopausal Indonesian women with osteoporosis - A preliminary study

Widya Dwi Honesty Putri Soewarlan, Hedijanti Joenoes, Shafa Ahmad Bawazier, Dwi Anita Suryandari, Elza Ibrahim Auerkari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Osteoporosis is a condition that is characterized by reduced bone mass and micro-architectural deterioration. Previous studies have shown that the MTHFR C677T polymorphism may be involved in the development of osteoporosis. The aim of this study was to characterise the distribution of this polymorphism in 100 Indonesian postmenopausal women. The MTHFR C677T polymorphism were determined in 25 women with osteopenia, 50 women with osteoporosis, and 25 control subjects using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique with Hinf1 enzyme. The results showed CC genotype (wild type) 70%, CT genotype (heterozygous polymorphic) 29%, and TT genotype (homozygous polymorphic) 1%, with a T-allele frequency of 15.5%. The result also showed that there was no significant variation with MTHFR C677T genotype. It can be concluded that the MTHFR C677T polymorphism was weakly associated with BMD (Bone Mineral Density).

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • Bone mineral density
  • MTHFR
  • osteoporosis
  • polymorphism

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