Dissolution enhancement of lansoprazole using cocrystallization

Silvia Surini, Dian Novitasari, Arry Yanuar

Research output: Contribution to journalArticle

Abstract

Objective: Lansoprazole (LPZ) is a Biopharmaceutics Classification System Class II drug. It has low solubility and high permeability, so its rate of dissolution is a rate-limiting step for drug absorption. This study aimed to improve the dissolution rate of LPZ by forming cocrystals, using nicotinamide (NCT) as the conformer. Methods: Cocrystals of LPZ were produced using the solvent evaporation and solvent-drop grinding methods with a molar ratio of 1:1 and 1:2. The cocrystals were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), and differential scanning calorimetry (DSC). The solubility and dissolution of the LPZ cocrystals were examined in distilled water. Results: FTIR was used to confirm the formation of hydrogen bonds between LPZ and NCT. DSC and XRD studies showed the formation of crystals from cocrystals and a decrease of the melting point of the cocrystals. The dissolution study revealed that the cocrystals could increase the LPZ dissolution rate by up to 8.4-fold compared with pure LPZ. Conclusion: LPZ cocrystal formation with NCT was successful in increasing the dissolution rate of LPZ.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalInternational Journal of Applied Pharmaceutics
Volume12
Issue numberSpecial Issue 1
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Cocrystals
  • Dissolution rate
  • Lansoprazole
  • Nicotinamide

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