Diphtheria Toxin Repressor (dtxR) Gene-Based Genetic Diversity of Corynebacterium diphtheriae Isolated in Jakarta, Indonesia, 2018–2019

Andi Yasmon, Paulina Rosa Evriarti, Yeva Rosana

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aim: In Indonesia, diphtheria cases caused by Corynebacterium diphtheriae are still occurring. One of the causes is probably the diphtheria toxin repressor (dtxR) gene, which influences toxin expression. In this study, the gene was characterized to determine the mutations that affect the DtxR protein.
Materials and Methods: The dtxR genes of 10 C. diphtheria strains isolated in Jakarta were amplified by conventional PCR. The PCR products were directed to DNA sequencing by using overlapping primers.
Results & Conclusion: No mutations showed amino acid changes. We propose that the DtxR protein is conserved among bacterial strains isolated from Jakarta.
Original languageEnglish
Pages (from-to)262-266
JournalIranian Journal of Medical Microbiology
Volume17
Issue number2
Publication statusPublished - 2023

Keywords

  • Corynebacterium diphtheriae
  • dtxR
  • Mutation
  • Phylogeny tree

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