Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines

Fadilah Fadilah; Hadin Abdurrohman; Ericko Ongko Joyo; Vallas Aditiar Widodo; Rahardi Prasetia Priawan; Fatmawaty Yazid; Rafika Indah Paramita; Erni Hernawati Purwaningsih

Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines

Fadilah Fadilah, Hadin Abdurrohman, Ericko Ongko Joyo, Vallas Aditiar Widodo, Rahardi Prasetia Priawan, Fatmawaty Yazid, Rafika Indah Paramita, Erni Hernawati Purwaningsih

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC ₅₀ values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.

Original language	English
Pages (from-to)	S1451-S1455
Journal	Asian Journal of Pharmaceutics
Volume	12
Issue number	4
Publication status	Published - 1 Oct 2018

Keywords

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromideassay
Clove(SyzygiumaromaticumL.)
Direct scanning calorimetry
Michigan cancer foundation-7
Nanoparticle

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Fadilah, F., Abdurrohman, H., Joyo, E. O., Widodo, V. A., Priawan, R. P., Yazid, F., Paramita, R. I., & Purwaningsih, E. H. (2018). Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines. Asian Journal of Pharmaceutics, 12(4), S1451-S1455.

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title = "Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines",

abstract = " Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC 50 values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.",

keywords = "3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromideassay, Clove(SyzygiumaromaticumL.), Direct scanning calorimetry, Michigan cancer foundation-7, Nanoparticle",

author = "Fadilah Fadilah and Hadin Abdurrohman and Joyo, {Ericko Ongko} and Widodo, {Vallas Aditiar} and Priawan, {Rahardi Prasetia} and Fatmawaty Yazid and Paramita, {Rafika Indah} and Purwaningsih, {Erni Hernawati}",

year = "2018",

month = oct,

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language = "English",

volume = "12",

pages = "S1451--S1455",

journal = "Asian Journal of Pharmaceutics",

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Fadilah, F, Abdurrohman, H, Joyo, EO, Widodo, VA, Priawan, RP, Yazid, F, Paramita, RI & Purwaningsih, EH 2018, 'Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines', Asian Journal of Pharmaceutics, vol. 12, no. 4, pp. S1451-S1455.

Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines. / Fadilah, Fadilah; Abdurrohman, Hadin; Joyo, Ericko Ongko et al.
In: Asian Journal of Pharmaceutics, Vol. 12, No. 4, 01.10.2018, p. S1451-S1455.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines

AU - Fadilah, Fadilah

AU - Abdurrohman, Hadin

AU - Joyo, Ericko Ongko

AU - Widodo, Vallas Aditiar

AU - Priawan, Rahardi Prasetia

AU - Yazid, Fatmawaty

AU - Paramita, Rafika Indah

AU - Purwaningsih, Erni Hernawati

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC 50 values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.

AB - Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC 50 values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.

KW - 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromideassay

KW - Clove(SyzygiumaromaticumL.)

KW - Direct scanning calorimetry

KW - Michigan cancer foundation-7

KW - Nanoparticle

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SN - 0973-8398

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SP - S1451-S1455

JO - Asian Journal of Pharmaceutics

JF - Asian Journal of Pharmaceutics

IS - 4

ER -

Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines

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