Differential scanning calorimeter profiling for the determination of nanoparticle ethanol extract of clove (Syzygium aromaticum L.) toward Michigan cancer foundation-7 human breast cancer cell lines

Fadilah, Hadin Abdurrohman, Ericko Ongko Joyo, Vallas Aditiar Widodo, Rahardi Prasetia Priawan, Fatmawaty Yazid, Rafika Indah Paramita, Erni Hernawati Purwaningsih

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This research was conducted to evaluate in vitro assay of nanoparticles ethanol extract of cloves toward Michigan Cancer Foundation-7 human breast cancer cell lines. Materials and Methods: In this research, we have synthesized bud clove extract nanoparticles and analyzed with differential scanning calorimetry. The cytotoxic activity of extract, nanoparticles, and its bioactive component was investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and analyzed by ELISA reader. Results: The in vitro test showed that the IC 50 values of the extract and the nanoparticles were 20.13 μg/mL and 7.6 μg/mL, respectively. Conclusion: The ethanol extracts of clove (Syzygium aromaticum L.) could be formulated in nanoparticles form. From cytotoxicity assay, nanoparticle of clove extract showed better cytotoxic activity than the ethanol extract.

Original languageEnglish
Pages (from-to)S1451-S1455
JournalAsian Journal of Pharmaceutics
Volume12
Issue number4
Publication statusPublished - 1 Oct 2018

Keywords

  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromideassay
  • Clove(SyzygiumaromaticumL.)
  • Direct scanning calorimetry
  • Michigan cancer foundation-7
  • Nanoparticle

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