Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis

Agnes Kurniawan, M. Yazdanbakhsh, R. Van Ree, R. Aalberse, M. E. Selkirk, F. Partono, R. M. Maizels

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

A population of 164 adult individuals resident in an area endemic for Brugia malayi lymphatic filariasis has been studied for humoral immune responses to filarial parasites. Antibody levels to Ag extracted from adult worms were determined for each of the IgG subclasses, for IgM and for IgE. The dominant isotype of antifilarial antibody was IgG4, which represented 88% of total IgG in asymptomatic microfilaremics, most of whom possessed 100 to 1000 μg/ml of specific antibody of this subclass (geometric mean 762 μg/ml). Patients with chronic disease (elephantiasis), who were generally amicrofilaremic, had substantially higher levels of IgG1, IgG2, and IgG3, but a 3.4-fold lower geometric mean level of specific IgG4 (222 μg/ml) than asymptomatics with or without microfilaremia. In contrast, specific IgE antibody levels in cases of elephantiasis were on average 4.5 times higher than those found in the asymptomatic carrier state. The majority of microfilaremics were therefore typified by extremely high specific IgG4 concentrations and relatively low IgE reactivities, whereas clinical cases tended to show the reverse relationship. The possible roles of these isotypes and the implications of changing IgG4/IgE balances in disease are discussed.

Original languageEnglish
Pages (from-to)3941-3950
Number of pages10
JournalJournal of Immunology
Volume150
Issue number9
Publication statusPublished - 1 Jan 1993

Fingerprint Dive into the research topics of 'Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis'. Together they form a unique fingerprint.

  • Cite this

    Kurniawan, A., Yazdanbakhsh, M., Van Ree, R., Aalberse, R., Selkirk, M. E., Partono, F., & Maizels, R. M. (1993). Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. Journal of Immunology, 150(9), 3941-3950.